Brain Injury Hope

Cord blood or MSC ?

Just 2 very interesting studies :

1) « behavioural deficit was significantly improved with multiple doses of cord blood, but not with a single dose. We also showed that the injury caused significant loss of brain tissue and cell death, which was only improved in the study arm that administered multiple doses of cord blood cells. “

Article:

https://parentsguidecordblood.org/en/news/multiple-doses-cord-blood-are-better-cerebral-palsy-animal-model

And second :

2) This was made on animal model but UCB seems to be batter choice than MSC….

So a lot to think….

« This study is the ﬁrst to compare the neuroprotective efﬁcacy ofUCB cells versus MSCs for inﬂammation-induced preterm braininjury. Both UCB cells and MSCs have protective beneﬁts for thepreterm brain, but their effects on white matter are different.MSCs were strongly anti-inﬂammatory, dampening multipleindices of brain inﬂammation at the cellular and gene level. Incontrast, UCB cells showed a reduced ability to mediateneuroinﬂammation, but importantly, prevented apoptosis-mediated cell death and protected mature myelinating oligoden-drocytes. These differential effects of UCB and MSCs are likely dueto speciﬁc actions of an isolated cell population (MSCs) versus astem/progenitor cell mix (UCB). «

https://www.researchgate.net/publication/331658814_Umbilical_cord_blood_versus_mesenchymal_stem_cells_for_inflammation-induced_preterm_brain_injury_in_fetal_sheep

« CONCLUSION

In response to LPS-induced preterm brain injury, administration of

MSCs had a global effect on dampening brain inﬂammation,

which in turn may have detrimental effects on brain repair and

normal development. MSCs did not improve survival of critical

oligodendrocytes and did not prevent apoptosis-mediated cell

death. In contrast, UCB was neuroprotective against cell death and

normalized the number of mature myelinating oligodendrocytes, but did not display the same anti-inﬂammatory effects as MSCs.

Our results indicate that UCB is a more comprehensive therapy for

protecting white matter brain development, likely contributed by

the mixed cell population in UCB, and their differential actions. »

thé problème i think we need be very careful with dosing MSC:

« In contrast, MSCs require expansion by tissue culture

and are a much larger cell (average 25 μm), limiting the

concentration that can be administered in a single dose without

risk of embolism. »

And

« Therefore, a global dampening of inﬂammatory mediators with MSC administration (as seen in the directional change of the bars

in Fig. 4) may interrupt normal brain development and it may be

such that reducing an aberrant pro-inﬂammatory cerebral

response with cell treatment is preferable. MSC treatment

decreased white matter expression of IGF-1, which is essential

for normal oligodendrocyte maturation produced by multiple cell

types within the CNS, particularly the glial cells.

Indeed, IGF-1 is

proposed as a rescue therapy for hypomyelination,

and protective for oligodendrocytes. »

« The dampening of inﬂammation and growth factor expression

by MSCs may be a concern, further investigation into this ﬁnding

is required. »

08/07/1908/07/19

Pons and Cp

Pons:

“It is traditionally considered that a child with cerebral palsy reaches half of its potential to develop motor skills by the age of 5 years and the maximum possible development by 7 years. The potential achieved remains at the same level or may even worsen with age. In our experiments, all children were over the age of 7 years. These results can significantly expand both the scope of this technology in the rehabilitation of children with cerebral palsy and improve the prediction of the effectiveness of the therapy used for older children.

Brain TLNS enhances the effect of physical rehabilitation, activating vast areas of the brain, increases the efficiency of existing neural networks, increases the likelihood of new synaptic contacts (synaptogenesis), enhances the brain’s innate ability to improve motor function. The fMRI data alone confirms that the human brain is plastic at any age and is capable of an amazing reorganization, the mechanisms of which we are just beginning to explore. The dynamics of changes in DMN and functional connections between the first and second timepoints turned out to be more vivid than between the first and third timepoints. That probably indicates a delayed rehabilitation effect.”

https://www.researchgate.net/profile/Yuri_Danilov/publication/334400894_Translingual_Neurostimulation_in_Late_Residual_Stage_Cerebral_Palsy_Children_Treatment_Affects_Functional_Brain_Networks/links/5d278d21299bf1547cad2e17/Translingual-Neurostimulation-in-Late-Residual-Stage-Cerebral-Palsy-Children-Treatment-Affects-Functional-Brain-Networks.pdf

05/30/1905/30/19

Latest publication 2019 with Pons mesures brain activity in high-density EEG

“Microstate effects suggest that even during rest, the PoNS® may elicit functional changes in the brain that are associated with evidence of increased neuroplasticity-related improvements.

Neuromodulation, such as through the PoNS®, has been linked to improved functional outcome in brain injury and disease, but the underlying neural mechanisms remain elusive. We report the initial findings of EEG changes in resting brain activity after a single 20-min session of PoNS®. While both HF and LF PoNS® dosage levels produced significant changes in alpha and theta wave activity, HF stimulation showed differential dosage effects. HF PoNS® also significantly increased attentional microstates suggesting a possible functional mechanism associated with evidence of neuroplasticity improvements. Overall, these findings support continued characterization of the underlying neural mechanisms related to the use of neuromodulation to drive recovery of function through neuroplasticity.”

Fig. 2

a Comparison of alpha EEG power before and after PoNS®, displaying statistically significant main effect of time; (b) Order by time interaction effect on alpha and theta power and Tukey pairwise post-hoc test statistical tests demonstrating a statistically significant increase alpha and theta power when exposed to HF stimulation in the first session; (c) Time-frequency spectral power for each exposure group (HF First and LF First) during each testing session:

Source:

https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-019-0538-4

05/07/1907/18/19

We are starting soft hbot for Marc:

I honestly believe that soft chamber can also help in many ways but I think it’s not the best for a period of time right after his injury but on the other hand 100% oxygen has more potential right after an injury from my point of view.

I’ll be honest; I do understand that parents can’t always go to clinics every year, or twice a year for 2 months…. ( in order to do 40 dives).

Just to give you an exemple:

We did four months in Israel’s Hbot back in 2016 ( which was the best thing that could happened to Marc) so it was the period when oxygen 100% helped him mostly and it was more potential because more close to injury in time.

we also did one month in 2017 and then two months in 2018

So in total we did 110hours of hard chamber (1,5ata 100% oxygen) in 3 years.

Both of the two last times, we saw progress which was much less obvious than at his first time in 2016 and it’s totally normal.

So now we are sold on soft chamber: it’s obvious it still helps him but I really think that I would do it now at 1,3 ata without oxygen, not because it’s my favorite protocol, but because it’s safe for home use. In those circumstances it would give less results but everyone is able to do it at home which by the way makes it 50% more oxygen in his plasma that will help him.

So it’s just obvious, we can not escape school every year for 2 months. So I believe that a soft chamber can be THE solution for long term treatment (we are talking years after the acute injury).

And by the way we have some good canadien group testimonials from parents (in french only) who mostly used soft chamber treatments only.

Here’s our chamber installation :

Thanks

Jean-François Tremblay

contact:

www.oxysoins.com

info@oxysoins.com

It was an exeptional experience, very helpful for installation and for all of my questions and just perfectioning training.

(francais):

Nous commençons souple hbot pour Marc:

Honnêtement, j’ai la conviction que la chambre souple peut aussi aider de nombreuses manières, mais j’estime que ce n’est pas la meilleure solution pour une période qui suit immédiatement sa anoxie cérébrale , mais que 100% d’oxygène a au plus de potentiel après son arrêt cardiaque (c’est que de mon point de vue) …après 110h chambre dure 100% oxygene et 1,5 ata on passe à chambre souple à la maison 1,3 ata et sans oxygène et après 3 ans!

Je serai honnête; Je comprends que les parents ne peuvent pas toujours aller aux cliniques chaque année, une ou deux fois par an pendant 2 mois … (pour faire 40 plongées).

Juste pour vous donner un exemple:

On a fait pendant 3 ans En Israël, nous avons Hbot dure (1,5 ata 100% oxygène) –

pendant quatre mois en 2016 (ce qui a été la meilleure chose qui puisse arriver à Marc). C’est donc la période où l’oxygène à 100% l’a aidé le plus, ce qui lui donnait plus de potentiel, car il était plus proche de son anoxie cérébrale dans le temps.

nous avons également fait un mois en 2017 puis deux mois en 2018

Au total, nous avons donc effectué 110 heures de chambre dure (1,5% à 100% d’oxygène) en 3 ans.

Les deux dernières fois, nous avons constaté des progrès beaucoup moins évidents que lors de sa première fois en 2016 et c’est tout à fait normal.

Nous sommes maintenant commence le chambre souple : c’est évident que peut l’aider toujours, mais je pense vraiment que je le ferais maintenant à 1,3 ata sans oxygène, non pas parce que c’est mon protocole préféré, mais parce que c’est sans danger pour la maison. Dans ces circonstances, cela donnerait moins de résultats, mais tout le monde est capable de le faire à la maison, ce qui lui donne 50% d’oxygène supplémentaire dans son plasma, ce qui l’aidera.

C’est donc évident, nous ne pouvons pas échapper de l’école tous les ans pendant 2 mois. Je pense donc qu’une chambre souple peut être LA solution pour un traitement à long terme (nous parlons des années après anoxie cérébrale).

Et au fait, nous avons de bons témoignages de groupes canadiens de la part de parents qui utilisaient principalement des traitements de chambre souple : https://www.facebook.com/groups/169622703606007/?ref=share

Voici notre installation de chambre:

Merci

Jean-François Tremblay

Si vous voulez contact:

www.oxysoins.com

info@oxysoins.com

Tel france : 0186655685

Ce fut une expérience exceptionnelle, très utile pour l’installation et pour toutes mes questions et pour perfectionner ma formation.

05/02/1905/08/19

Here’s the video of Dr. Kurtzberg speaking at the New Horizon Arizona Stem Cells conference -April 2019

Here’s the video of Dr. Kurtzberg speaking at the New Horizon Arizona Stem Cells conference :

(April 2019)

https://www.facebook.com/1115496706/posts/10218506814957717?s=1115496706&v=i&sfns=mo

7:30mins discuss male cells getting into brain of CP

Hydrocortisone reduces fevers

12mins starts to talk about autism

19mins only male donors for the cord tissue trial are being used but doesn’t mention if male are better than female. Taken from c-section babies (interesting as c-section implies potential complications). They expand the cells to passage 2. Each cord produces about 60billion expanded cells, amounting to 60 to 100 doses (@ 2million cells per kilo).

23mins one child didn’t use Benadryl and started coughing from transfusion, resolved with the use of Benadryl.

25:40mins hypoxic brain injury helped with cord blood. But beneficial effects stopped when CD14 cells are removed!

33mins slide with cell characteristics for CP trial.

36mins gross motor improvements seen in CP study. Higher doses showed better results. Would love to know what the higher dose is versus the smaller dose.

40:40mins suggesting a cord blood transfusion followed by an MSC booster.

47mins they have over 2000 families on their wait list which is over a years work for them.

If you can’t see hole video on my Facebook please try on YouTube ( I separated in 3 parts):

Part 1:

https://youtu.be/OVAaUpNzCEY

Part 2:

https://youtu.be/RUaxU4Hga_w

Part 3:

https://youtu.be/pmJ6dVlgK3s

And I will put all power points Photos ( sorry not in in order of presentation):

04/15/1907/18/19

So why Hbot works not always same way in brain injury?

So why Hbot works not always same way in children’s? I am not a doctor I am just a mum like you so please I do analyze my son injury I read a lot but I am not a doctor ( take it just only mum reflection on subject) ok?

It’s very difficult question and I think even best Hbot doctors don’t know exact answer honestly

Let’s say : first of all each brain injury is unique and diferent.

I am trying just analyzing what I can as dates but as I said with anoxic brain injuries we don’t have any studies with spect scans so all this discussion just my personal suppositions ok ?

Ok i post mri of Marc before Hbot and after 80h

We have MRI in January 2016 just some days after anoxic injury

And we have MRI June 2017 after 80h Hbot … but without general anesthesia ( so some artifacts)

Be my guest if any radiology specialist want to make professional hole comparison

1. I think Age of child in the moment of injury play very big role : of child very small ( new born or HIE child for example) smaller is a child at brain injury more fragile his brain ( so same 25 minutes without oxygen will be more devastating on smallest child brain at birth or 1 month age than at 4 years old)

Second why age is important – because if child was already walking / full functioning child before brain injury -so after it will be retraining of his lost functions wile in new born it will be just training ( with less neurons in brain) I think it’s more difficult. But it’s just my opinion.

2. Of cause most important factor : it’s volume of Brain which was damaged!!!!

While there is no way of knowing how much recoverable tissue exists in the days, weeks, and years following brain injury , HBOT can increase cell reproduction and administer oxygen to tissue that was previously cut off from blood flow. The dormant cells surrounding the damaged tissue area, also known as ischemic penumbra, are responsible for much of post-stroke dysfunction. If oxygen therapy can revive these cells, lost functionality may return to the individual.

And this you can say only by MRI and Spect. But again for small children’s I am sorry but MRI don’t give exact informations ( that’s why neurologists don’t like to do MRI for cp children’s too early age …. we can really see at age 4-5 years but before it’s very difficult).

But still : Qualitative assessment of brainstem injury on T1 and T2 images in neonates with HIE may provide information on injury severity and risk of death, but objective quantitative data such as ADC values are lacking. ( if you want to read about read this study:

https://www.ncbi.nlm.nih.gov/m/pubmed/28686592/

These infratentorial areas have high concentrations of excitatory neurotransmitters (e.g., glutamate) and are especially vulnerable to the profound hypoxia-ischemia that is typical in HIE. The cerebellum acts as a satellite system of established cortico-basal ganglia networks in neonates.

If we talk about MRI of my child ( he had basal ganglia

and thalamus damages) …

In one large study cohort, 60% to 70% of infants who sustained moderate basal ganglia/thalamic injury had cerebral palsy and 35% had developmental quotient less than 70 (40). Cerebral palsy was identified in 98% of infants with severe basal ganglia/thalamic injury

Before Hbot:

I will post his MRI ( after Hbot a bit father in this article ok?)

3. So here we come fore 3d factor : did child was cooled after brain injury???? I believe that it’s helped to my child ( yes his body temperature was cooled it’s protocol for cardiac arrest but not always for HIE ).

4. Did child had 100% oxygen or just 30% oxygen delivery as Normobaric ? It’s may be has also role to play i think.

( it’s after reading this book I think about )

This lecture is also really good explanation why Hbot is better ( than Normobaric oxygen) we get oxygen in plasma! Lisen at 44minutes :

https://youtu.be/z6qy1hq2zqM

( and by the way I agree about multiple approach with Sherr – before starting Hbot in Israel’s for my son – we did batteries of blood tests and also tubes in ears – in order to protect them against barotraumatisme).

5. And you see naw what I think about Hbot ( we don’t have real agreement between doctors what is the best protocol for brain injury – and what kind brain injury ? By the way ?) TBI or anoxic? ). Parents has some possibilities: 1,5ata 100% oxygen is most used in hard chambers by centers ( sometimes is more pressure but honestly it’s the mostly use regiment for nerology in hard chambers) and I believe that in case of my son really oxygen in Hbot made biggest changes but as I posted before in Hbot conditions contrary to Normobaric 100% oxygen…

« We found that HBO, but not NBO, reduced oxygen and glucose deprivation-induced cell injury, indicating that passive tissue oxygenation (i.e. without vascular support) of the brain parenchyma requires oxygen partial pressure higher than 1 ATA. »

Haw about being accepted by friends in school for « special » children’s ? A propos d’être accepté par des amis à l’école pour des enfants « spéciaux »?

I will tell you my point of vue on this question :

Marc has a lot of friends

But honestly I did maximum in order to get all children’s and parents « on my sight « after Marc accsident at the beginning it was not obvious …

It’s exactly what I am doing :

Social life is very very important target so during 2 years II worked for this goal for Marc

I see results this year …( I have a chance because I am « not working mum » but in fact I do my job exactly this way : who can invite 5-6 neurological normal friends at home every week and play with them during 3-4 hours per day????….. so I am not working mum who do it for my child… i think I invest better than any proffecionel in this point….)

But I need professionals in parts I can’t do… 😉

Others parents don’t want to do efforts for your child ( or at least not much who will do)

It’s like this

It’s reality

When you know this and do all yourself without counting on them everything is easygoing…

And if it’s interesting to come to your home to theirs children’s they will ask to come from their parents and so … you will start invite for weekend for cake and coffee …. so you start create sosial links with parents and children’s….

Just don’t wait that they will invite you in reteurn

It’s will be always you who will do much more than others parents 😉

Yes it’s the best motivation for my son Marc so that’s why I do my own “friends” programm and every week planing ( yes you need to send messages /phone calls in order to plan 5-6 invitations per week).

Often parents they don’t have time / motivation to play with theirs children’s at home ( I do have this time and my hasbend is playing with kids just exeptional during weekends ! They love to play with him)

I know 11 children’s from his class and parents and we continue doing new friends of cause absolutely!

(so well I know to play with them in social games somtimes can be very boring for adults and we as parents somtimes wants just to rest I know all this! ) I have à chance naw Marc can a bit play just alone between children’s but it wasn’t so evident 2 years ago …

and yes somtimes I am inviting 2 his best friends ( boys) to sleep at home so we can have pyjamas parties 😉 and dansing 😉

Yes I will tell you it’s a lot of job /coking/playing

But it’s worth 😉

But you can’t imagine what I feel this year when children’s I don’t know yet from his class comme to me and ask : “ please can you invite me to eat with Marc?” I am also in his clas I am his friend”… and so – I ask marc” hey you know this boy you want invite him home?”

And his pleasure to tel me yes I want yes he is playing with me at school ….or So other day “mum can you invite this boy …etc…”

This is really cool feeling….

A lot of job but so cool!

🙂

It is a long way but it’s worth !

AS said it took me 2 years to get back Marc socialisation after his Sudden Cardiac Arrest.

I started with 2 best friends invited regulary at home ( for 2-3 hours) – weekend.

Than I started to invite friends to eat with Marc at home during lunches ( it’s of cause me who organize all I am going to school taking children’s / make them eat together and playing – and bring them back to school) – parents need only tell to school that they give me permission to take their children’s for lunch ( so not much trouble for other parents or any trouble for their daily plans)

Naw I am in fact : at level 3 lunches per week ( every time I invite only one friend )

And Friday evening – very often he is playing with friends ( after school)

And 2 others children’s for 4 hours invited to play each Saturday and Sunday !

Yah planing for Ministry of Foreign Affaires has less appointments 😉

( exept week-end we travel of cause)

So 6 friends per week!

It’s a real job I have 😉

Kids club

But it’s so worth it!

And if you know haw Marc is happy to has all his friends !

Et maintenant en français : ( désolé mon français n’est pas parfait … mais ça m’empêche pas ni parler ni écrire 😉

Je vais vous dire mon point de vue sur cette question: Marc a beaucoup d’amis!

Mais honnêtement j’ai fait le maximum pour avoir tous les enfants et parents «à ma vue» après l’accident de Marc au début ce n’était pas évident …

C’est mon travail de maman de lui aider pour acceptation sociale, je compte pas sur Ecole où metresse pour ça ( ils ont assez de travail déjà…) mais même pour les enfants « nerotypic » c’est aussi pas tout les enfants qui sont accepter donc pourquoi ? …. je me souviens quand j’étais petite un garçon ( ordinaire) en classe été très » populaire » …. son père investis beaucoup a l’école – organiser et participer dans sortie de l’école et des jeux » organisés de l’école » tout les enfants de l’école connaissait lui c’esta père de Valera et ce garçon en faite – était tes populaire par ce que son père a aider de devenir comme ça….. donc j’ai beaucoup réfléchis….

C’est exactement ce que je fais: la vie sociale est une cible très très importante donc pendant 2 ans j’ai travaillé pour cet objectif pour Marc.

Je vois des résultats cette année …2019-2020

(J’ai une chance car je ne «travaille pas» mais en fait je le fais mon travail exactement de cette façon: qui peut inviter 5-6 amis neurologiques normaux à la maison chaque semaine et jouer avec eux pendant 3-4 heures par jour ???? ….. donc je ne travaille pas officiellement – je suis une maman qui » travaille » que pour mon fils qui le ferait pour moi enfant … sauf moi???? Personne…. est que on peut réussir faire ça en restant maman qui travail – et lesse école gérer vie sociale de leur enfant ? Je ne sais pas….

je pense que j’investis mieux que n’importe quel proffecionel dans ce point peut faire. Mais j’ai besoin de professionnels dans des parties que je ne peux pas faire …( pas pour son vie sociale pour reheducations biensure) 😉

Les autres parents ne veulent pas faire des efforts pour votre enfant – surtout si il a un handicap – ils ont aussi PEUR de prendre quelconque responsabilité pour votre enfant – et c’est normal – ils ont peur…..(ou à du moins pas beaucoup qui fera inviter votre enfant en retour)….. si vous l’accompagner – pour les anniversaires – oui biensure ils inviteront !!!!

C’est comme ça

C’est la réalité

Quand vous savez cela et faites tout vous-même sans compter sur eux tout devient claire et facile…

Et s’il est intéressant de venir chez vous pour les enfants, ils demanderont à leurs parents de venir ( fait en sorte que vôtre maison devienne très intéressant pour eux à venir – un endroit où ils s’amuse vraiment super bien – camp de vacances ! ) et donc … vous commencerez à inviter le week-end pour un gâteau et un café …. alors vous commencerez à créer des liens sosiaux avec parents et enfants …. N’attendez pas qu’ils vous invitent en retour – quelque parents feront mais c’est vraiment pas important que vous le feraient 10 fois plus – par se que en fin compte c’est vôtre enfant qui sera gagnant.

Ca sera toujours vous qui ferez bien plus que les autres parents ( eux ils travail ! Et eux ils ont pas » besoin » de faire un effort supliment aire pour vie sociale de leur progéniture) c’est logique.

Oui c’est la meilleure motivation pour mon fils Marc donc c’est pour ça que je fais le mien “ programme d’amis et planification hebdomadaire (oui, vous devez envoyer des messages / appels téléphoniques pour planifier 5-6 invitations par semaine- in organisation et planing de » ministre » que c’est à vous – maman de gérer….Souvent, les parents n’ont pas le temps / la motivation pour jouer avec leurs enfants à la maison (moi j’ai ce temps et motivation et mon mari aussi joue avec les enfants juste pendant les week-ends! Ils adorent jouer avec lui même bien plus que avec moi 🙂

Je connais 11 enfants de sa classe maintenant ( et on continue à faire Nouvaux copains toujours ) et leurs parents biensure .

Je sais t’es bien que parfois jouer avec eux des jeux sociaux peut parfois être très ennuyeux pour les adultes et nous, en tant que parents, on veut parfois juste se reposer, je sais tout cela! Mais ça n’est pas thème de cet article ….

J’ai une chance que maintenant Marc peut jouer un peu seul ( avec un copain ou un copine) sur mon surveillance mais là après 2 ans il y a des moments que je peut les lesser juer LEGO un peut ou playMobiles entre les enfants mais ça ce n’était pas si évident il y a 2 ans … et oui, j’invite parfois 2 de ses meilleurs amis (garçons) à dormir à la maison pour que nous puissions faire des soirées pyjamas 😉 et danser ou juer « 1,2,3 soleil « , je vais vous dire que c’est beaucoup de boulot / je suis devenu un animatrice presque professionnel ….tien un future bulo à clubMed? ( pour ma retraite )…

Mais ça vaut le coup : vous pouvez pas d’imaginer ce que je ressens cette année quand des enfants que je ne connais pas encore de sa classe viennent me voir et me demandent: » tu est Maman de Marc. S’il te plaît, peux-tu m’inviter à manger avec Marc? je suis son ami « … et donc – je demande à mon fils Marc » tu connais ce garçon tu veux l’inviter à la maison? « Et son plaisir de me dire -« oui je veux oui il joue avec moi à l’école …. ou alors l’autre jour « maman peux-tu inviter ce garçon … etc … » C’est vraiment un sentiment très agréable…. Beaucoup de travail mais tellement cool! 🙂C’est un long chemin mais ça vaut le coup! Comme j’ai déjà dit qu’il m’a fallu 2 ans pour retrouver la socialisation de Marc après son arrêt cardiaque soudain.

J’ai commencé avec 2 meilleurs amis – les invités régulièrement à la maison (pendant 2-3 heures) – le week-end. J’invite toujours ( sauf anniversaire) un seul copain à la fois …. c’est plus facile à gérer et c’est mieux pour Marc. Ensuite, j’ai commencé à inviter des amis à manger avec Marc à la maison pendant les déjeuners (c’est parce que moi qui organise tout ce que je vais à l’école en emmen les enfants / je les fait à manger ensemble et jouer – et je les ramene à l’école après ) – les parents n’ont qu’à dire à l’école qu’ils me donnent la permission de prendre leurs enfants pour le déjeuner (donc pas trop de problèmes pour les autres parents et aucun problème pour leurs habitudes quotidiens).

A ce jour je suis en fait: au niveau 3 déjeuners par semaine (chaque fois que j’invite un seul ami) Et chaque Vendredi soir – très souvent il joue avec des amis (après l’école) Et 2 enfants pendant 4 heures invités à jouer chaque samedi et dimanche!

Oui emplois de temps de ministre….Donc 5- 6 amis par semaine! C’est un vrai travail je gère clubKids ou clubMed à la maison mais ça en vaut la peine! Et si vous le savez, comment Marc est heureux d’avoir tous ses amis!

Voilà mon livre « Marc L’invincible » est désormais en ligne et disponible* à l’achat dans la boutique Kindle: ( en français)

https://www.amazon.fr/dp/B07Y34WPXQ

« Marc L’invincible: L’histoire vraie d’une récupération remarquable, après arrêt cardiaque et lésions cérébrales anoxiques », est désormais disponible en livre broché dans la boutique Amazon. Les lecteurs peuvent l’acheter:

https://www.amazon.fr/dp/B07Y4KC5S1

Here is my book « Marc L’invincible » is now online and available * for purchase in the Kindle store: (in French)

04/06/1904/07/19

Normobaric or Hyperbaric?

1)Hyperbaric oxygen and hyperbaric air treatment result in comparable neuronal death reduction and improved behavioral outcome after transient forebrain ischemia in the gerbil:

« hyperbaric oxygen may represent a potentially important therapeutic option for post-arrest encephalopathy as well as other forms of brain injury. We also agree that animal studies of global brain ischemia suggest that hyperbaric oxygen may be beneficial with regard to neurologic outcome »

Anoxic brain injury resulting from cardiac arrest is responsible for approximately two-thirds of deaths. Recent evidence suggests that increased oxygen delivered to the brain after cardiac arrest may be an important factor in preventing neuronal damage, resulting in an interest in hyperbaric oxygen (HBO) therapy. Interestingly, increased oxygen supply may be also reached by application of normobaric oxygen (NBO) or hyperbaric air (HBA). However, previous research also showed that the beneficial effect of hyperbaric treatment may not directly result from increased oxygen supply, leading to the conclusion that the mechanism of hyperbaric prevention of brain damage is not well understood. The aim of our study was to compare the effects of HBO, HBA and NBO treatment on gerbil brain condition after transient forebrain ischemia, serving as a model of cardiac arrest.

Source :

https://www.researchgate.net/publication/234042951_Hyperbaric_oxygen_and_hyperbaric_air_treatment_result_in_comparable_neuronal_death_reduction_and_improved_behavioral_outcome_after_transient_forebrain_ischemia_in_the_gerbil

2. this one also :Effects of normobaric versus hyperbaric oxygen on cell injury induced by oxygen and glucose deprivation in acute brain slices

https://www.google.fr/amp/s/www.researchgate.net/publication/308753914_Effects_of_normobaric_versus_hyperbaric_oxygen_on_cell_injury_induced_by_oxygen_and_glucose_deprivation_in_acute_brain_slices/amp

03/29/1906/30/19

CD14 cells in cord blood that is special and helps repair brain cells from low oxygen in brain or hypoxic injury

About stem cells :

Watch this dr Kurtzberg presentation ( in English from 12 minutes)

https://m.youtube.com/watch?feature=youtu.be&v=IZ7GeQ3mM7M

From the 20:54, Dr Joanne Kurtzberg says It’s the CD14 cells in cord blood that is special and helps repair brain cells from low oxygen in brain or hypoxic injury

And as I know nobody doing yet hole donor cord blood HLA matched exept Duke ( and yet in clinical trails)….

More on Dr Kurtzberg’s presentation of the good monocytes in cord blood cells:

10:38 [Referring to cord blood cells]…and about 10% are a kind of cells called the monocyte. Monocyte in cord blood is unique and it’s the cell that we think is helping patients with cp and autism. And we don’t think it’s helping because it’s engrafting in the brain or turning into neurons or turning into brain cells. We think it’s helping because it puts out chemicals that signal cells that’s already in the brain to repair damage.

human UCB (hUCB) is a complex internal environment rich in a variety of stem/progenitor cell populations, such as hematopoietic stem cells (HSCs), endothelial progenitor cells (EPCs), UCB monocytes (including T regulatory cells (Tregs) and monocyte-derived suppressor cells (MDSCs)) and MSCs…etc….

UCB mononuclear/ whole blood cells in the perinatal ischemic and hypoxic brain model can reduce the inflammatory response to treat injury. To evaluate whether transplanted cells relieve neuroinflammation, there are two indicators:

(1) reduce the infiltration of CD4 þ T cells into the brain; and (2) reduce microglial activation.

all UCB cell types except EPCs have CNS immunoregulatory capacity.

Tregs and monocytes are present in the normal body at a considerable level, and are indispensable in the regulation of peripheral and central immune responses.

« Currently, the use of UCB-based interventions for CP is limited as the components of UCB are complex and possess different therapeutic mechanisms. These can be categorized by three aspects: homing and neuroregeneration, trophic factor secretion, and neuroprotective effects. »

https://www.researchgate.net/publication/328690064_A_New_Approach_to_Cerebral_Palsy_Treatment_Discussion_of_the_Effective_Components_of_Umbilical_Cord_Blood_and_its_Mechanisms_of_Action

There are several paper about cord blood CD14+ cells neuroprotective action ( CB Monocytes – CD14+ cells protect brain cells from Oxygen and Glucose Deprivation in Cortex). Even more: cord blood cells contain many neurotrophic factors, which are very important for brain regeneration.

•Brain-derived neurotrophic factor,

Nerve growth factor-

•Neurotrophin-3 –

•Neurotrophin-4 –

•Glial cell-derived neurotrophic factor –

•Cerebral dopamine neurotrophic factor –

•Mesencephalic astrocyte-derived neurotrophic factor

•Pigment epithelium-derived factor.

https://www.researchgate.net/publication/289510468_CD14_human_umbilical_cord_blood_cells_are_essential_for_neurological_recovery_following_MCAO

Latest Duke publication about CD14:

https://cdn.fbsbx.com/v/t59.2708-21/61565783_397700577506188_2233617151242010624_n.pdf/670794.full.pdf?_nc_cat=105&_nc_oc=AQm-qC11yqS79HyUmrkqnToptSZJxSHk4ULPH1L2INIazkDe9vro0UHWF1fubLjHPxE&_nc_ht=cdn.fbsbx.com&oh=094475c2789b013855fecdc8d8bdda6d&oe=5D1B23DB&dl=1

03/24/1906/03/19

Selective percutaneous myofascial lengthening (Dr Nuzzo operation)

It’s exist study for Splm 😉

And video :

https://youtu.be/Mk6aAgERlNo

« 68 (SPML) and functional physiotherapy are an alternative to traditional open surgical lengthening and 70 physiotherapy respectively, for improving functional mobility in children with CP that have muscle

contractures and stiffness (Mansour et al2017; Mitsiokapa et al., 2010).

Here study of SPLM dr Nuzzo operation ( yes clinical study exist):

http://e-n-a.gr/uploads/1-s2.0-S0891842209001323.pdf

As well as study for « Improving gait and lower-limb muscle strength in children with cerebral palsy following selective percutaneous myofascial lengthening and functional physiotherapy »

https://tree.sci-hub.tw/2819aa58c58aa79814b4c00d8c6ddc5e/skoutelis2018.pdf

What is the difference between SPLM and Microfibrilotomy or Ulzibat methode? I don’t know honestly it’s looks very similar but I am not orthopedic surgeon ok?

More about Microfibrilotomy or Ulzibat methode you can find in this article :

http://brain-injury-hope.com/2019/02/microfibrilotomy-or-ulzibat-methode-just-my-research-on-subject/