Just 2 very interesting studies :
1) « behavioural deficit was significantly improved with multiple doses of cord blood, but not with a single dose. We also showed that the injury caused significant loss of brain tissue and cell death, which was only improved in the study arm that administered multiple doses of cord blood cells. “
Article:
And second :
2) This was made on animal model but UCB seems to be batter choice than MSC….
So a lot to think….
« This study is the first to compare the neuroprotective efficacy ofUCB cells versus MSCs for inflammation-induced preterm braininjury. Both UCB cells and MSCs have protective benefits for thepreterm brain, but their effects on white matter are different.MSCs were strongly anti-inflammatory, dampening multipleindices of brain inflammation at the cellular and gene level. Incontrast, UCB cells showed a reduced ability to mediateneuroinflammation, but importantly, prevented apoptosis-mediated cell death and protected mature myelinating oligoden-drocytes. These differential effects of UCB and MSCs are likely dueto specific actions of an isolated cell population (MSCs) versus astem/progenitor cell mix (UCB). «
« CONCLUSION
In response to LPS-induced preterm brain injury, administration of
MSCs had a global effect on dampening brain inflammation,
which in turn may have detrimental effects on brain repair and
normal development. MSCs did not improve survival of critical
oligodendrocytes and did not prevent apoptosis-mediated cell
death. In contrast, UCB was neuroprotective against cell death and
normalized the number of mature myelinating oligodendrocytes, but did not display the same anti-inflammatory effects as MSCs.
Our results indicate that UCB is a more comprehensive therapy for
protecting white matter brain development, likely contributed by
the mixed cell population in UCB, and their differential actions. »
thé problème i think we need be very careful with dosing MSC:
« In contrast, MSCs require expansion by tissue culture
and are a much larger cell (average 25 μm), limiting the
concentration that can be administered in a single dose without
risk of embolism. »
And
« Therefore, a global dampening of inflammatory mediators with MSC administration (as seen in the directional change of the bars
in Fig. 4) may interrupt normal brain development and it may be
such that reducing an aberrant pro-inflammatory cerebral
response with cell treatment is preferable. MSC treatment
decreased white matter expression of IGF-1, which is essential
for normal oligodendrocyte maturation produced by multiple cell
types within the CNS, particularly the glial cells.
Indeed, IGF-1 is
proposed as a rescue therapy for hypomyelination,
and protective for oligodendrocytes. »
« The dampening of inflammation and growth factor expression
by MSCs may be a concern, further investigation into this finding
is required. »