The recent evidence for HBOT efficacy in brain repair and the new understanding of brain energy management and response to damage opens new therapeutically fields that will be further investigated in the upcoming years.

Very interesting article ( from pediatric doctor who had herself TBI and did Hyperbare in Israel)

https://www.haaretz.com/1.5003649

https://www.ncbi.nlm.nih.gov/m/pubmed/29804339/

Video :

Video is in English do listen it: (it’s explain really well about brain and why hbot can help neurological conditions : it’s started with strokes than TBI than fibromyalgia etc….)

https://vimeo.com/226711472

« Clinical studies published in the last 3 years present convincing evidences that hyperbaric oxygen therapy (HBOT) can be the coveted neurotherapeutic method for brain repair. HBOT is a treatment in which oxygen-enriched air (up to 100%) is administrated to patients in a chamber where the pressure is elevated above 1ATA (one atmosphere absolute, which is the ambient atmospheric pressure). It is now realized, that the combined action of hyperoxia and hyperbaric pressure, leads to significant improvement in tissue oxygenation while targeting both oxygen and pressure sensitive genes, resulting in improved mitochondrial metabolism with anti-apoptotic and anti-inflammatory effects. In addition, the oxygen fluctuation generated by HBOT stimulates stem cells proliferation, HIF increased (The hyperoxide paradox) and brain angiogenesis. The lecture will introduce the current understanding of the multi-faceted role of HBOT in neurotherapeutics and the new understanding of brain energy management and response to trauma in general  »

Source :http://pracdemia.haifa.ac.il/index.php/en/23-kit-cat/video/161-hyperbaric-oxygen-therapy-basics-and-neurological-applications-the-case-of-childhood-trauma-shai-efrati

( I will say study wich makes people argue)….

Will be 1,3 ata without oxygen enough for CP?

Or 1,5ata with 100% oxygen is better ???

This is the question ! Is only one study enoth to answer it? I don’t know….

Are all children’s with CP need same protocol ?

🙂

http://hyperbaricstudies.com/wp-content/uploads/Hyperbaric-Therapy-Based-Multimode-Therapy-for-children-with-Cerebral-Palsy.pdf

here the study comparing 1,3 ata air

With 1,5ata

With 1,75 ata

( it was published by Dr Arun Mukerjee India):

Please see his conclusions :

So in fact conclusion is that all Hbot groups give improvements with no significant differences …. and that more study neded….

An this study was made in India with help of dr Marois (Canada)…..

In fact, this study compares the use of various hyperbaric pressures with the use of (ambient) air alone or oxygen-enrichment in the treatment of children with Cerebral Palsy (CP). The study shows that low pressure ambient air hyperbaric therapy (1.3 atmospheres-ATA) is also effective not only high pressure 100% oxygen (1.5 or 1.75 ATA) in the treatment of CP.

The children were studied by Dr. Arun Mukherjee, director of the UDAAN Disabled Children’s Center, a non-profit organization, recognized and aided by the Indian Ministry of Social Justice & Empowerment.

This landmark study, co-authored with Dr. Pierre Marois (McGill University in Montreal, Canada), further develops the 1999 ground-breaking McGill study (Lancet, February 2001) by expanding the number of subjects and by implementing an accurate placebo-control testing method. Subjects with a functional diagnosis of spastic diplegia cerebral palsy received one of four hyperbaric options, in addition to standard therapies:

1) the placebo therapy (20 subjects);

2) hyperbaric therapy at 1.3 ATA breathing ambient air under pressure (36 subjects);

3) hyperbaric therapy breathing 100% oxygen at 1.5 ATA (32 subjects); and

4 ) 1.75 ATA with 100% oxygen (58). All subjects were reevaluated at six months after conclusion of therapy to negate any traces of the placebo effect.

The study showed significant improvements FOR ALL THREE GROUPS receiving therapy hbot !!!!!(the placebo group showed little or no improvement).

They mentioned in study that 1,3 ata could be an option for parents who can’t afford 1,5 ata to get far degree of improuvments (read also please paragraph about chambers problems…)

They also mentioned in study:

…..”it is possible that the cp child with greater motor dysfunction will be slightly better with regular hbot 1,5 ata 100% oxygen”

So we need more studies to be shure which pressure is better for cp … in meantime wile we have no such studies I will be happy if parents with CP child trying any law neurological pressure …( better with Hbot doctor guidence ) so any law pressure 1,3 or 1,5 or 1,75 ….

Read all study… in details and do best you can for your children’s 😉

Bottom line ( pressure) is nobody really knows yet which is the best protocol.

Weakness if this study: absence of spect scans for all 3 groups with Hbot treatments before treatment and after.

As dr Efrati said in his research: « Unfortunately, in many – if not most – clinical studies done with hyperbaric oxygen on brain-in- jured patients, including those with cerebral palsy, the stunned areas have not been assessed by imaging. The anatomical/physiological imaging should be incorpor- ated as an essential part of the basic evaluation of every candidate for hyperbaric oxygen therapy. »

This study in India was done without any spect or MRI ….

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

But what firsthand we have to think when we talk about brain injury and CP: obviously more studies are needed!

And i think parents can help in someway to push for Hbot if we contact enough gouvernements / researchers/ media’s we need to take Hbot in the “light “ in order that general population knows about and that Hbot can help neurological conditions we need work all together not in separate camps… 😉 and doctors have to stop taking -us – parents like we are absolutely stupid 😉

( unfortunately we have some doctors which thinks we can only listen their orders) we are also need to study ( parents) and we can also bring some informations to doctors if they wants to listen us 😉

“Clearly, large-scale, well-controlled, pressure dose- response studies are required to determine the optimal HBO2 therapy protocol for different conditions. Until such information is available, any treatment involving change in the environmental pressure should be con- sidered as a dose-comparison rather than a sham-control study. Moreover, since at a young age, brain protection is stronger (reflected by high ROS levels associated with CP) and neuroplasticity is more potent, it is reasonable to expect that optimal efficacy will be achieved by lower tissue oxygenation. Along such line of reasoning, the previously described trials used 2.0 atm abs for post- stroke patients and 1.5 atm abs for patient with mTBI with an intact macrovascular bed [23,24]. Due to the high diversity in the manifestation of cerebral palsy and in its severity, future efforts should also be directed towards a personalized dose-response curve. For example, it is likely that higher tissue oxygenation will be the practice of choice for children with a high expression of ApoE4, which is an inhibitor of mitochondrial respiration.”

And : “One must bear in mind that children with CP suffer neurological deficiency since birth, so it will take time for the brain repair to become clinically apparent. For example, it is not reasonable to administer 20 daily HBO2 sessions to children with pervasive developmental disorders (PDD) and expect to see significant clinical progress within a time frame of less than a month [25].

On the other hand, it is important to perform fre- quent metabolic/physiological evaluations, which may provide valuable information for adjusting the dose- response curve. More studies are needed to determine the minimal effective dosage and the treatment duration for specific brain injuries. Non-invasive, in-chamber measurements that are currently being developed, speci- fically EEG and DTI, may shed some light on this important question.”

And: “the optimal candidate for hyperbaric oxygen is a patient with unrecovered brain injury where tissue hypoxia is the limiting factor for the regeneration processes. In this patient, HBO2 may induce neuroplasticity in the stunned regions where there is a brain anatomy/physiology (e.g., SPECT/CT) mismatch [23,”

Source:

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

Hire what Study from Israel yet in 2016 about hbot and PSC (Persistent post-concussion syndrome caused by mild traumatic brain injury )

I am sure in 2018 they have much more data’s ( because naw they are doing study for children’s):

Results will be published in 2019

So we will talk about results of this trail in 2019 if you wants 😉

( I saw children’s and discussed with parents our last time we was in Israel May 2018…..so at least I know what parents alredy saw…)

It’s the first randoased trail for hbot and concussion in children’s :

https://clinicaltrials.gov/ct2/show/NCT03339037

Persistent post-concussion syndrome caused by mild traumatic brain injury has become a major cause of morbidity and poor quality of life. Unlike the acute care of concussion, there is no consensus for treatment of chronic symptoms. Moreover, most of the pharmacologic and non-pharmacologic treatments have failed to demonstrate significant efficacy on both the clinical symptoms as well as the pathophysiologic cascade responsible for the permanent brain injury. This article reviews the pathophysiology of PCS, the diagnostic tools and criteria, the current available treatments including pharmacotherapy and different cognitive rehabilitation programs, and promising new treatment directions. A most promising new direction is the use of hyperbaric oxygen therapy, which targets the basic pathological processes responsible for post-concussion symptoms; it is discussed here in depth.

(PDF) Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions.

Available from:

https://www.researchgate.net/publication/304362194_Treatment_of_persistent_post-concussion_syndrome_due_to_mild_traumatic_brain_injury_current_status_and_future_directions

[accessed Dec 04 2018].

16 symptoms of PCS on a 0 to 4 scale (King 1995). Thèses 16 symptoms are: headaches, feelings of dizziness, nausea or vomiting, noise sensitivity, sleep disturbance, fatigue, being irritable, feeling depressed or tearful, feeling frustrated or impatient, forgetfulness, poor concentration, taking longer to think, blurred vision, light sensitivity, double vision, and restlessness. Imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), are useful to detect underlying abnormal findings, such as mild subarachnoid haemorrhage, subdural hematomas, and contusions for mTBI patients (Borg 2004). Other advanced imaging techniques, such as diffusion tensor imaging (DTI) and single photon emission computerised tomography (SPECT), may also be useful to diagnose abnormal findings for PCS patients after mTBI (Agrawal 2005; Khong 2016).

Hyperbaric oxygen therapy (HBOT) has been proposed as a therapy to improve the symptoms of PCS.

Regeneration following damage to the brain after mTBI requires additional energy. HBOT may increase oxygen levels in the blood and body tissues, thus supplying sufficient oxygen for converting the energy through aerobic metabolism into a usable form for cellular function needed for brain repair. The elevated blood oxygen level may have several restorative effects on damaged brain cells, such as increasing blood flow, improving metabolism, triggering neuroplasticity, and activating angiogenesis (Golden 2002; Hadanny 2015; Tal 2015). HBOT may also increase cell proliferation, induce oxidative stress resistance, and may affect changes in gene expression (Godman 2010).

Dans cet article, je vous raconte l’histoire de cette petite fille: Céleste du Québec.

Céleste est une belle petite fille de 2 ans et demi qui vit avec la maladie de Lyme.

Petite fille c’est fait mordre à l’oreille par un tique et c’était pas dans un bois profond…. et c’était fin octobre 2017 en plain vile du Québec.

« La maladie de Lyme, une infection bactérienne causée par Borrelia burgdorferi et transmise à l’homme par la piqûre de tiques à pattes noires infectées, est la maladie à transmission vectorielle la plus répandue aux États-Unis. La manifestation caractéristique de la maladie de Lyme, un érythème migrant autour de la morsure de la tique Les analyses de laboratoire peu optimales sont une option de diagnostic peu fiable pour un maximum de 20% des patients qui ne présentent pas de symptômes objectifs. Des antibiotiques administrés au début de la maladie guérissent jusqu’à 90% des personnes infectées. « 

Heureusement les parents ont a fait des séances en caisson Hyperbare à la clinique:

https://oxysoins.com/

Voici ici un témoignage de sa maman Valérie Dupont

Bonne lecture !

source de article :

https://www.facebook.com/359171110831552/posts/1940271836054797/

« Ni la maladie de Lyme ni la CLD ne sont des indications approuvées pour l’HBO ( hbot), et il existe peu de preuves pour appuyer l’utilisation de HBO ( hbot), sur cette maladie déroutante, bien que des cas d’amélioration spectaculaires aient été rapportés. Création de registre dans ses cas sera outil de mieux comprendre le nombre de patients traités et permettra déterminer si l’HBO ( hbot) l’a ou non un effet bénéfique sur cette maladie troublante et controversée. Ce registre pourrait servir de véhicule aux essais prospectifs nécessaires pour générer des preuves potentielles en faveur de l’utilisation de l’HBO ( hbot) sur la maladie de Lyme. « 

Source :

https://link.springer.com/chapter/10.1007%2F978-3-319-47140-2_15

article dans journal Express:

Pour lire plus loin lien:

http://www.journalexpress.ca/actualite/fillette-piquee-par-une-tique-le-film-dhorreur-perdure/?fbclid=IwAR0sLmhbHb2u15Znz67nV8T2yylNN-c3R9vZS4SYaFuOy5VNWZpq32m0Wp4

English :

« Lyme disease, a bacterial infection caused by Borrelia burgdorferi and transmitted to humans by the bite of infected blacklegged ticks, is the most common vector-borne disease in the United States. The hallmark manifestation of Lyme disease, an erythema migrans around the tick bite, is found on most infected persons. Less than optimal laboratory testing is an unreliable diagnostic option for up to 20 % who present without objective symptoms. Antibiotics administered early on in the disease cure up to 90 % of infected persons. 

……Neither Lyme disease nor CLD is an approved indication for HBOT, and evidence is scarce to support the use of HBOT on this confusing disease, although some dramatic cases of improvement have been reported. An HBOT registry for Lyme disease and CLD would be an important tool to better understand the number of patients treated and whether or not HBOT has a beneficial effect on this puzzling and controversial condition. This registry could serve as the vehicle to perform the prospective trials that are needed to generate potential evidence to support the use of HBOT on Lyme disease. »

Source :

https://link.springer.com/chapter/10.1007%2F978-3-319-47140-2_15