So Israël will start randomized HBOT trail for COVID19 ?

So here study in Israel will start soon:

https://clinicaltrials.gov/ct2/show/NCT04358926

The purpose of Israel’s study is to evaluate the efficacy of HBOT in moderate-severe COVID-19 patients in a randomized controlled manner.

This Swiss study and also some studies in USA ( with hbot) still makes me think that hbot may be good therapie for COVID19 patients :

I will explain 

Hère Swiss last study: ( published in Lancet)

This is new interesting study:

« The endothelial tissue of younger patients is usually capable of coping well with the attacks launched by the virus. The situation is different for patients suffering from hypertension, diabetes, heart failure or coronary heart diseases, all of which have one thing in common – their endothelial function is markedly impaired. If patients such as these become infected with SARS-COV-2, they will be particularly at risk, as their already weakened endothelial function will diminish even further, especially during the phase in which the virus reproduces the most.  « 

Study:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext

Link to Swiss article :

http://www.en.usz.ch/media/press-releases/pages/covid-19-endotheliitis.aspx?DeviceChannel=Mobile

So in fact they talk about :

Endothelial dysfunction  And capacity to produce nitric oxide (NO)….

And we have a lot of studies ( with hbot) One of them Shai study:

« In a study on rats with normal mitochondrial function, HBOT increased the production of adenosine triphosphate in muscle tissue compared to a control group [29]. Moreover, in a clinical study by Li et al., it was demonstrated that HBOT may improve myocardial blood perfusion, reduce inflammation and vascular endothelial dysfunction, and further improve myocardial microcirculation in patients after the implantation of drug-eluting stents [30]. Aparci et al. evaluated the changes following a series of 10 hyperbaric sessions in diabetic patients [31] »

https://www.researchgate.net/publication/338667041_The_effect_of_hyperbaric_oxygenation_therapy_on_myocardial_function

So if  HBOT improve myocardial blood perfusion, reduce inflammation and vascular endothelial dysfunction we are searching improve level of NO ( in all types cardiac patients) so I think for such category of patients may be hbot could be used even before any COVID19 infection ?.. ( may be than if their capacity to produce nitric oxide (NO)will be normalise or almost) we will see much more less cardiac person with bad Covid 19 outcome ????

This study as well…. 

https://www.researchgate.net/publication/321256684_Effects_of_hyperbaric_oxygen_on_vascular_endothelial_function_in_patients_with_slow_coronary_flow

why Professor Raoult’s protocol is not tested stricto sensu in the Discovery trial?

I would like to know why Professor Raoult’s protocol is not tested stricto sensu in the Discovery trial?

As a reminder, the Raoult protocol is: hydroxychloroquine (200 mg x 3 per day for 10 days) + Azithromycin (500 mg on the 1st day then 250 mg per day for 5 more days)

the Raoult protocol made so much noise that the state was obliged to include it in its European discovery trial ….. but not its protocol

Study: https://www.sciencedirect.com/science/article/pii/S0924857920300996

Didier Raoult (born March 13, 1952 in Dakar, Senegal) [1] is a French physician and microbiologist. He holds M.D. and Ph.D. degrees and specializes in infectious diseases. In 1984, Raoult created the Rickettsia Unit at Aix-Marseille University (AMU). He also teaches infectious diseases in the Faculty of Medicine of Aix-Marseille University, and since 1982 has supervised many M.D. and Ph.D. degrees. [2]

https://en.wikipedia.org/wiki/Didier_Raoult

It is the only molecule which is no longer under patent of the protocol so they do not want it, but since it made a fuss, to calm everyone, they include chloroquine in the European test but not following the right protocol like that it will not work and they can say: well here you see we listened to you

Like that everyone happy.

They could not think that like you we are a lot because we are informed to have understood that the purpose of including chloroquine in the test is to discredit it.

It is exactly the same for the chloroquine restriction decree which authorizes its use for severe cases (by our French government) where the Raoult protocol highlights the low efficacy of chloroquine in severe cases!

there are over 30 clinical trials registered on clinicaltrialsdotgov right now for hydroxychloroquine. not just treating covid-19 infected but prophylactic treatment of health care professionals treating covid-19 patients. so doesn’t mean they are ethics approved. but wow.

Meanwhile, 3 big names in health-management in France support Raoult …

Dominique Maraninchi, Fabien Calvo and Jean-Luc Harousseau, former directors and presidents of the ANSM, the HAS and the INCA.

https://www.lefigaro.fr/vox/societe/chloroquine-l-appel-de-trois-grands-noms-de-la-sante-en-faveur-des-preconisations-du-pr-raoult-20200405

But they are saying Hydroxychloroquine-COVID-19 study did not meet publishing society’s “expected standard”:

https://retractionwatch.com/2020/04/06/hydroxychlorine-covid-19-study-did-not-meet-publishing-societys-expected-standard/

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