Duke study for ASD children’s with allogenic and autologous cord blood

“In a subanalysis of children without intellectual disability (ID), allogeneic, but not autologous, CB was associated with improvement in a larger percentage of children on the clinician-rated Clinical Global Impression-Improvement scale”

And: “Children without ID treated with CB showed significant improvements in communication skills (VABS-3 Communication Domain), and exploratory measures including attention to toys and sustained attention (eye-tracking) and increased alpha and beta electroencephalographic power.”

“The rationale is that CB CD14+ monocytes act through paracrine signaling to modulate brain inflammation and/or immune abnormalities, improving brain function and behavior.”

“One hundred eighty children, aged 2-7 years (mean ± SD, 5.47 ± 1.65) who met DSM-5 criteria for ASD participated. Diagnosis was based on the Autism Diagnostic Observation Schedule-217 and Autism Diagnostic Interview, Revised.18 Participants were screened for a genetic cause of ASD with testing for Fragile X and chromosomal microarray. Inclusion criteria included (1) negative genetic testing, (2) qualified CB unit with a minimum banked total nucleated cell dose of ≥2.5 × 107 cells/kg or ≥4/6 HLA-matched allogeneic unrelated CB unit, (3) stable on medications for ≥2 months, (4) ability to travel to study site twice, (5) English speaking, and (6) normal absolute lymphocyte count (≥1500/μL).”

But : “Infused dose was not associated with the primary and secondary outcomes, with the exception of the CGI. The allogeneic cohort received a higher TNC dose compared with the autologous cohort (3.8 × 107/kg vs 2.7 × 107/kg) making it impossible to determine whether the effect in the allogeneic group was due to the higher cell dose or to CB type.”

“When participants with NVIQ ≥70 were analyzed separately, the results indicated that participants without ID who were treated with CB exhibited significantly increased relative alpha powerposterior/toys (P = .02) and significantly increased relative beta1 powerall brain regions/social (P = .02) compared with the placebo group (Figure 5). No main effects were found for theta or gamma power.”

“However, for children without ID, clinician CGI ratings indicated that children treated with allogeneic CB, but not those treated with autologous CB, showed improvement over placebo. Children without ID also showed significantly greater improvement in a prespecified secondary outcome measure of VABS Communication SS when treated with CB compared with placebo.”

https://www.jpeds.com/article/S0022-3476(20)30334-6/pdf

Book / livre en 2 langues français and English

English links:

Finally we did My Book publication in English:

Marc The Invicible: A true story of my son’s resurrection from cardiac arrest followed by anoxic brain damage

SERIGNY SVETLANA , LUQUET JULIE , RICHARDSON ANNETTE

Kindle format:

https://www.amazon.com/Marc-Invicible-resurrection-cardiac-followed-ebook/dp/B088QQQKSZ

Paper book:

https://www.amazon.com/dp/B088T26YXB

Français:

Voilà mon livre : en 2 possible versions « Marc L’invincible » ( en français)

Kindle:

https://www.amazon.fr/dp/B07Y34WPXQ

en livre broché sur Amazon:

https://www.amazon.fr/dp/B07Y4KC5S1

EXO serum or haw I found best cream for me while studying cord blood ….

Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin!!!!

https://www.researchgate.net/publication/319867439_Exosomes_derived_from_human_umbilical_cord_blood_mesenchymal_stem_cells_stimulates_rejuvenation_of_human_skin

And : https://www.researchgate.net/publication/322179874_Exosomes_from_human_umbilical_cord_blood_accelerate_cutaneous_wound_healing_through_miR-21-3p-mediated_promotion_of_angiogenesis_and_fibroblast_function/fulltext/5a4ad7b4aca272d29464762d/322179874_Exosomes_from_human_umbilical_cord_blood_accelerate_cutaneous_wound_healing_through_miR-21-3p-mediated_promotion_of_angiogenesis_and_fibroblast_function.pdf?origin=publication_detail

Denise Serigny my mother in law send me her testimonial for EXO: (she does not have Facebook now) and she is 78 years old!

But this is her experience after 6 months:

“What a pleasure to put on my face, morning and evening, this little drop of EXO.

Immediately i felt my skin becomes “full” of this elixir and in a few seconds nourishes and beautifies it.

I always thought, that i will become “old » in natural way… I would never resort to cosmetic surgery, I want to keep on my face the traces of my history.

EXO, suits me fully : gradually reducing fine wrinkles and slightly filling the skin , giving it a « healthy glow » effect.”

Description EXO :

https://lookaside.fbsbx.com/file/%D0%9E%D0%BF%D0%B8%D1%81%D0%B0%D0%BD%D0%B8%D0%B5%20EXO%20Serum%20EN.docx?token=AWy2Sz8l3W6w561lS1nsuoXDsydkHlabdndHPLlA82ufjp-06XiLoelL9vyUark5zQpa9w5S9HEDshJNivzo5ztEvnLzj-6WIUynR2GFxGv74c6Dmte9WfcytegvGmw–OoUmNIMMub0aAzZp2pYPue05NQsdrU0cEdHQfuBPzHTspduQb5KtCVEefB6OOPLoMtKEE8kXRMaLt3NtgjreeZe

A lot of friends ask me how to maintain youth and look good at my age (I’m 46 on the left of photo) …so ….honestly, I think several factors play a role …

Of course genetics; nutrition and physical activity … but for the skin …. not only …. my friends often ask me what cream I use …. I honestly did not use any;) before….but recently we drove to treat our son brain injury in Samara and there I found a cream on a natural basis – based on exosomes ….from umbilical cord blood .. (I studed a lot of scientific literature on umbilical cord blood as you can find in previous articles on my blog….for my son and therefore I know a lot about its capabilities) therefore it was this serum with exosomes that I personally was interested to give a try and honestly the result on my face became already visible after 2 months!

I can testify that after 8 months of treatment an excellent result on my face skin really great some wrinkles are less visible (but the result is absolutely natural) not like the stretched and inflated faces of Botox stars …oh … the horror … 😂

I am 46 years old, and I am very pleased with EXO serum, it is effective, soft and natural – and, in my opinion, it is ideal (I am not a supporter of Botulique toxins and not a supporter of plastic surgeries – I consider this exagération – in pursuit of “rejuvenation” and results …. haw to say – better to use in horror films- very unnatural and doubtful …. and it could harm your health ! Botox can harm you it’s toxic…..

Of cause at the same time, as any woman I’m looking for a way to stay attractive – but as “natural” as possible and therefore I personally really like EXO Serum.

It should be noted that this is not just external beauty, but also real skin health and restoration of skin functions! So very very healthy !!!!

Exosomes of umbilical cord mesenchymal cells have proven effective for skin rejuvenation in preclinical studies by a group of scientists from the USA and China. Experiments have shown that exosomes can potentially be used to regenerate and rejuvenate the skin with various defects. The work was published in ACS Omega magazine:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941387/

Exosomes have the ability to stimulate the proliferation of dermal fibroblasts, as well as enhance their production of collagen, elastin and fibronectin.

As I wrote earlier, EXO underwent research in Samara for burns and healing wounds.

Everything was perfectly explained long ago in the video: https://drive.google.com/file/d/1tICdE9m3KvrVelrWjTkXQeRta2NuKICL/view

I buy my face EXO serum in Russia! I live in france but I prefer this serum than any other big French marks of face creams and serums….

Here: Exo-store.ru

You want to see files find more videos and about see on fb page:

https://www.facebook.com/groups/537120110469531/?ref=share