Catégorie : HBOT Hyperbare

( I will say study wich makes people argue)….

Will be 1,3 ata without oxygen enough for CP?

Or 1,5ata with 100% oxygen is better ???

This is the question ! Is only one study enoth to answer it? I don’t know….

Are all children’s with CP need same protocol ?

🙂

http://hyperbaricstudies.com/wp-content/uploads/Hyperbaric-Therapy-Based-Multimode-Therapy-for-children-with-Cerebral-Palsy.pdf

here the study comparing 1,3 ata air

With 1,5ata

With 1,75 ata

( it was published by Dr Arun Mukerjee India):

Please see his conclusions :

So in fact conclusion is that all Hbot groups give improvements with no significant differences …. and that more study neded….

An this study was made in India with help of dr Marois (Canada)…..

In fact, this study compares the use of various hyperbaric pressures with the use of (ambient) air alone or oxygen-enrichment in the treatment of children with Cerebral Palsy (CP). The study shows that low pressure ambient air hyperbaric therapy (1.3 atmospheres-ATA) is also effective not only high pressure 100% oxygen (1.5 or 1.75 ATA) in the treatment of CP.

The children were studied by Dr. Arun Mukherjee, director of the UDAAN Disabled Children’s Center, a non-profit organization, recognized and aided by the Indian Ministry of Social Justice & Empowerment.

This landmark study, co-authored with Dr. Pierre Marois (McGill University in Montreal, Canada), further develops the 1999 ground-breaking McGill study (Lancet, February 2001) by expanding the number of subjects and by implementing an accurate placebo-control testing method. Subjects with a functional diagnosis of spastic diplegia cerebral palsy received one of four hyperbaric options, in addition to standard therapies:

1) the placebo therapy (20 subjects);

2) hyperbaric therapy at 1.3 ATA breathing ambient air under pressure (36 subjects);

3) hyperbaric therapy breathing 100% oxygen at 1.5 ATA (32 subjects); and

4 ) 1.75 ATA with 100% oxygen (58). All subjects were reevaluated at six months after conclusion of therapy to negate any traces of the placebo effect.

The study showed significant improvements FOR ALL THREE GROUPS receiving therapy hbot !!!!!(the placebo group showed little or no improvement).

They mentioned in study that 1,3 ata could be an option for parents who can’t afford 1,5 ata to get far degree of improuvments (read also please paragraph about chambers problems…)

They also mentioned in study:

…..”it is possible that the cp child with greater motor dysfunction will be slightly better with regular hbot 1,5 ata 100% oxygen”

So we need more studies to be shure which pressure is better for cp … in meantime wile we have no such studies I will be happy if parents with CP child trying any law neurological pressure …( better with Hbot doctor guidence ) so any law pressure 1,3 or 1,5 or 1,75 ….

Read all study… in details and do best you can for your children’s 😉

Bottom line ( pressure) is nobody really knows yet which is the best protocol.

Weakness if this study: absence of spect scans for all 3 groups with Hbot treatments before treatment and after.

As dr Efrati said in his research: « Unfortunately, in many – if not most – clinical studies done with hyperbaric oxygen on brain-in- jured patients, including those with cerebral palsy, the stunned areas have not been assessed by imaging. The anatomical/physiological imaging should be incorpor- ated as an essential part of the basic evaluation of every candidate for hyperbaric oxygen therapy. »

This study in India was done without any spect or MRI ….

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

But what firsthand we have to think when we talk about brain injury and CP: obviously more studies are needed!

And i think parents can help in someway to push for Hbot if we contact enough gouvernements / researchers/ media’s we need to take Hbot in the “light “ in order that general population knows about and that Hbot can help neurological conditions we need work all together not in separate camps… 😉 and doctors have to stop taking -us – parents like we are absolutely stupid 😉

( unfortunately we have some doctors which thinks we can only listen their orders) we are also need to study ( parents) and we can also bring some informations to doctors if they wants to listen us 😉

“Clearly, large-scale, well-controlled, pressure dose- response studies are required to determine the optimal HBO2 therapy protocol for different conditions. Until such information is available, any treatment involving change in the environmental pressure should be con- sidered as a dose-comparison rather than a sham-control study. Moreover, since at a young age, brain protection is stronger (reflected by high ROS levels associated with CP) and neuroplasticity is more potent, it is reasonable to expect that optimal efficacy will be achieved by lower tissue oxygenation. Along such line of reasoning, the previously described trials used 2.0 atm abs for post- stroke patients and 1.5 atm abs for patient with mTBI with an intact macrovascular bed [23,24]. Due to the high diversity in the manifestation of cerebral palsy and in its severity, future efforts should also be directed towards a personalized dose-response curve. For example, it is likely that higher tissue oxygenation will be the practice of choice for children with a high expression of ApoE4, which is an inhibitor of mitochondrial respiration.”

And : “One must bear in mind that children with CP suffer neurological deficiency since birth, so it will take time for the brain repair to become clinically apparent. For example, it is not reasonable to administer 20 daily HBO2 sessions to children with pervasive developmental disorders (PDD) and expect to see significant clinical progress within a time frame of less than a month [25].

On the other hand, it is important to perform fre- quent metabolic/physiological evaluations, which may provide valuable information for adjusting the dose- response curve. More studies are needed to determine the minimal effective dosage and the treatment duration for specific brain injuries. Non-invasive, in-chamber measurements that are currently being developed, speci- fically EEG and DTI, may shed some light on this important question.”

And: “the optimal candidate for hyperbaric oxygen is a patient with unrecovered brain injury where tissue hypoxia is the limiting factor for the regeneration processes. In this patient, HBO2 may induce neuroplasticity in the stunned regions where there is a brain anatomy/physiology (e.g., SPECT/CT) mismatch [23,”

Source:

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

Hire what Study from Israel yet in 2016 about hbot and PSC (Persistent post-concussion syndrome caused by mild traumatic brain injury )

I am sure in 2018 they have much more data’s ( because naw they are doing study for children’s):

Results will be published in 2019

So we will talk about results of this trail in 2019 if you wants 😉

( I saw children’s and discussed with parents our last time we was in Israel May 2018…..so at least I know what parents alredy saw…)

It’s the first randoased trail for hbot and concussion in children’s :

https://clinicaltrials.gov/ct2/show/NCT03339037

Persistent post-concussion syndrome caused by mild traumatic brain injury has become a major cause of morbidity and poor quality of life. Unlike the acute care of concussion, there is no consensus for treatment of chronic symptoms. Moreover, most of the pharmacologic and non-pharmacologic treatments have failed to demonstrate significant efficacy on both the clinical symptoms as well as the pathophysiologic cascade responsible for the permanent brain injury. This article reviews the pathophysiology of PCS, the diagnostic tools and criteria, the current available treatments including pharmacotherapy and different cognitive rehabilitation programs, and promising new treatment directions. A most promising new direction is the use of hyperbaric oxygen therapy, which targets the basic pathological processes responsible for post-concussion symptoms; it is discussed here in depth.

(PDF) Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions.

Available from:

https://www.researchgate.net/publication/304362194_Treatment_of_persistent_post-concussion_syndrome_due_to_mild_traumatic_brain_injury_current_status_and_future_directions

[accessed Dec 04 2018].

16 symptoms of PCS on a 0 to 4 scale (King 1995). Thèses 16 symptoms are: headaches, feelings of dizziness, nausea or vomiting, noise sensitivity, sleep disturbance, fatigue, being irritable, feeling depressed or tearful, feeling frustrated or impatient, forgetfulness, poor concentration, taking longer to think, blurred vision, light sensitivity, double vision, and restlessness. Imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), are useful to detect underlying abnormal findings, such as mild subarachnoid haemorrhage, subdural hematomas, and contusions for mTBI patients (Borg 2004). Other advanced imaging techniques, such as diffusion tensor imaging (DTI) and single photon emission computerised tomography (SPECT), may also be useful to diagnose abnormal findings for PCS patients after mTBI (Agrawal 2005; Khong 2016).

Hyperbaric oxygen therapy (HBOT) has been proposed as a therapy to improve the symptoms of PCS.

Regeneration following damage to the brain after mTBI requires additional energy. HBOT may increase oxygen levels in the blood and body tissues, thus supplying sufficient oxygen for converting the energy through aerobic metabolism into a usable form for cellular function needed for brain repair. The elevated blood oxygen level may have several restorative effects on damaged brain cells, such as increasing blood flow, improving metabolism, triggering neuroplasticity, and activating angiogenesis (Golden 2002; Hadanny 2015; Tal 2015). HBOT may also increase cell proliferation, induce oxidative stress resistance, and may affect changes in gene expression (Godman 2010).

Dans cet article, je vous raconte l’histoire de cette petite fille: Céleste du Québec.

Céleste est une belle petite fille de 2 ans et demi qui vit avec la maladie de Lyme.

Petite fille c’est fait mordre à l’oreille par un tique et c’était pas dans un bois profond…. et c’était fin octobre 2017 en plain vile du Québec.

« La maladie de Lyme, une infection bactérienne causée par Borrelia burgdorferi et transmise à l’homme par la piqûre de tiques à pattes noires infectées, est la maladie à transmission vectorielle la plus répandue aux États-Unis. La manifestation caractéristique de la maladie de Lyme, un érythème migrant autour de la morsure de la tique Les analyses de laboratoire peu optimales sont une option de diagnostic peu fiable pour un maximum de 20% des patients qui ne présentent pas de symptômes objectifs. Des antibiotiques administrés au début de la maladie guérissent jusqu’à 90% des personnes infectées. « 

Heureusement les parents ont a fait des séances en caisson Hyperbare à la clinique:

https://oxysoins.com/

Voici ici un témoignage de sa maman Valérie Dupont

Bonne lecture !

source de article :

https://www.facebook.com/359171110831552/posts/1940271836054797/

« Ni la maladie de Lyme ni la CLD ne sont des indications approuvées pour l’HBO ( hbot), et il existe peu de preuves pour appuyer l’utilisation de HBO ( hbot), sur cette maladie déroutante, bien que des cas d’amélioration spectaculaires aient été rapportés. Création de registre dans ses cas sera outil de mieux comprendre le nombre de patients traités et permettra déterminer si l’HBO ( hbot) l’a ou non un effet bénéfique sur cette maladie troublante et controversée. Ce registre pourrait servir de véhicule aux essais prospectifs nécessaires pour générer des preuves potentielles en faveur de l’utilisation de l’HBO ( hbot) sur la maladie de Lyme. « 

Source :

https://link.springer.com/chapter/10.1007%2F978-3-319-47140-2_15

article dans journal Express:

Pour lire plus loin lien:

http://www.journalexpress.ca/actualite/fillette-piquee-par-une-tique-le-film-dhorreur-perdure/?fbclid=IwAR0sLmhbHb2u15Znz67nV8T2yylNN-c3R9vZS4SYaFuOy5VNWZpq32m0Wp4

English :

« Lyme disease, a bacterial infection caused by Borrelia burgdorferi and transmitted to humans by the bite of infected blacklegged ticks, is the most common vector-borne disease in the United States. The hallmark manifestation of Lyme disease, an erythema migrans around the tick bite, is found on most infected persons. Less than optimal laboratory testing is an unreliable diagnostic option for up to 20 % who present without objective symptoms. Antibiotics administered early on in the disease cure up to 90 % of infected persons. 

……Neither Lyme disease nor CLD is an approved indication for HBOT, and evidence is scarce to support the use of HBOT on this confusing disease, although some dramatic cases of improvement have been reported. An HBOT registry for Lyme disease and CLD would be an important tool to better understand the number of patients treated and whether or not HBOT has a beneficial effect on this puzzling and controversial condition. This registry could serve as the vehicle to perform the prospective trials that are needed to generate potential evidence to support the use of HBOT on Lyme disease. »

Source :

https://link.springer.com/chapter/10.1007%2F978-3-319-47140-2_15

https://youtu.be/hEu4DxVfoVU

In this article i will tell you about this one more small girl : Eden Carlson

Her case was published and very famous her mother gave me permission to share her testimonials:

Eden, regenerated brain tissue at 1.3 ATA and room air with Dr. Harch. Her case of study:

http://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=144;epage=149;aulast=Harch

I post the exact words of Kristal Carlson mother of Eden:

“On February 29, 2016, our 23 month old daughter, Eden, got through a baby gate, pushed open a heavy door, and got into our swimming pool. The water was cold – about 45-50 degrees, not freezing. She was in the water 5-15 min. When I found her, she was cold and unresponsive. I immediately started CPR. Paramedics took over and then emergency room nurses. Eden had approximately 100 minutes of CPR and 17 shots of epi to get her heart beating again. The efforts of the paramedics, nurses, and doctors were truly heroic. Once stable, she was life flighted to Arkansas Children’s Hospital that evening. Her body was kept cold for 72 hours, and then they slowly warmed her up. Her kidneys and liver were not functioning and her blood was very acidic, but slowly she started to improve. She was extubated 11 days post accident and moved out of the PICU 13 days post accident. She spent 5 weeks total in the hospital. She suffered an anoxic brain injury mostly affecting the deep gray matter of her brain. She was fed by g tube and was in a vegetative state, unable to communicate or move her body with purpose. She was on baclofen for tone and propranolol and clonadine for neurostorming. We were told there was nothing more that mainstream medicine could do for her. We would have to ‘wait and see’ how she recovered. During this time we gave her double doses of fish oil, an herbal supplement called Vital Guard Supreme, and we diffused frankincense essential oil around her and rubbed it on the back of her neck several times per day.

We contacted Dr. Harch out of New Orleans a couple of weeks after Eden was released from the hospital. Approximately 8 weeks post accident, we started giving her normobaric oxygen, 3 L twice per day for 45 minutes by nasal cannula under Dr. Harch’s direction. Immediately after the first dose we saw a reduction in tone, she stopped squirming her severely postured body, and her eyes became more clear and focused. During the 2.5 weeks of this treatment at home, she began smiling and laughing, tracking with her eyes, saying about 10-15 words she recalled from before her accident, she regained her swallow and stopped drooling, started holding her head up, had a reduction in tone, and she started trying to use her hands to swipe at toys and grab. At 10.5 weeks post accident Eden started hyperbaric oxygen therapy (HBOT) under Dr. Harch’s care in New Orleans. After 4-5 treatments she could recall animal sounds, recall how to count to five, used her hands more, and she started trying to sit up.

During the two months we were in New Orleans Eden completed 40 HBOT sessions at 1.3 ATA on compressed room air. She had physical therapy twice per week. She had her g tube removed because she no longer required it. I weaned her from all prescription medication, as she no longer displayed a need for it. Almost all tone left her body. She could move her body with purpose. She could sit independently, scoot, pull herself to stand, and she started taking shaky steps by the end of her treatment. She regained all her vocabulary and speech abilities, plus more than she was capable of before her accident. She had a miracle recovery.

Her MRIs after 40 HBOT sessions were read as ‘normal’.

Today she has had over 100 HBOT sessions. She now has a soft chamber at home, and we continue treatment under Dr. Harch’s care. She walks well with assistance, and in all other ways she is a typical 4 year old child. Her cognitive abilities and speech are normal. She is always improving. Other than HBOT, she has attended the Plasticity Center in Orlando for one week. She has continuing occupational therapy 3 times per week. She has physical therapy 3 times per week – once in clinic, once in a pool, and once on horseback.

She is learning to swim”

Case of study:

Anoxic injury (near drowning) 2-year-old Eden Carlson’s road to recovery has defied the odds and is possibly the first medical case of its kind.case of study published:

http://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=144;epage=149;aulast=Harch

Article:

https://usat.ly/2gPEPT8

French:

Témoignage de Kristal Carlson

https://youtu.be/hEu4DxVfoVU

Dans cet article, je vous raconte l’histoire de cette petite fille: Eden Carlson

Son cas a déjà été publié et est très connu. Sa maman m’a donné la permission de diffuser son témoignage:

Eden, a régénéré son tissu cérébral à 1.3 ATA dans un caisson hyperbare à l’oxygène avec le Dr. Harch. Son cas a été étudié:

http://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=144;epage=149;aulast=Harch

Je poste les termes exacts de Kristal Carlson, la mère d’Eden:

“Le 29 février 2016, notre fille de 23 mois, Eden, a franchi une barrière de protection pour enfants, a ouvert une porte lourde et est tombée dans notre piscine. L’eau était froide – entre 7 et 10 DC, elle n’était pas gelée. Elle est restée de 5 à 15 minutes dans l’eau. Quand nous l’avons trouvée, elle était froide et ne répondait plus. J’ai immédiatement entrepris la réanimation cardio-pulmonaire. Les aides-soignants puis les infirmières de la salle d’urgence continuèrent. Eden a subi approximativement 100 minutes de réanimation cardio-pulmonaire et 17 chocs électriques pour que son coeur se remette à battre. Les efforts des aides-soignants, des infirmières et des médecins furent vraiment héroïques. Une fois son état stabilisé, elle fut amenée, en vie, par avion à l’hôpital pour enfants de l’Arkansas le soir même. Son corps a été refroidi pendant 72 heures, puis doucement réchauffé. Ses reins et son foie ne fonctionnaient plus et son sang était très acide, mais graduellement, elle commença à faire des progrès. Elle a été détubée 11 jours après l’accident et sortie des soins intensifs pour enfants 13 jours après l’accident. Elle a passé 5 semaines en tout à l’hôpital. Elle souffrait d’une blessure anorexique du cerveau affectant principalement la matière grise profonde de son cerveau. Elle était nourrie au moyen d’un tube et était dans un état végétatif, incapable de communiquer ou de se mouvoir volontairement. On lui donnait du Bacloféne pour son « tone » et du Propranolol et de la Clonadine pour son attaque cérébrale. On nous a dit que la médecine traditionnelle ne pouvait rien faire de plus pour elle. Il nous fallait attendre et voir comment elle allait récupérer. Pendant ce temps, nous lui avons donné une double dose d’huile de poisson, un complément de plante appelé Vital Guard Supreme, et nous avons diffusé de l’huile essentielle d’encens autour d’elle et en avons frotté l’arrière de son cou plusieurs fois par jour.

Nous avons contacté le Dr. Harch à la Nouvelle Orléans quinze jours après la sortie d’Eden de l’hôpital. A peu près, 8 semaines après l’accident, nous avons commencé à lui donner de l’oxygène normobare, 3  L deux fois par jour pendant 45 minutes à l’aide d’une canule nasale sous la supervision du  Dr. Harch. Immédiatement après la première dose, nous avons constaté une réduction de « tone », elle a arrêté de tortiller son corps qui était en très mauvaise position, et ses yeux devinrent plus clairs et concentrés. Pendant ces 2.5 semaines de traitement à la maison, elle a commencé à sourire et à rire, suivant des yeux, disant environ 10-15 mots dont elle se souvenait avant son accident, elle pouvait avaler à nouveau, et s’arrêta de baver, elle commença à redresser sa tête, eut une réduction de « tone », et a commencé d’utiliser ses mains pour saisir et déplacer ses jouets. 10.5 semaines après l’accident, Eden a commencé une thérapie d’oxygène hyperbare (HBOT) par le Dr. Harch à la Nouvelle Orléans. Après 4-5 traitements, elle pouvait se souvenir de bruits d’animaux, compter jusqu’à 5, mieux utiliser ses mains, et commencer à essayer de s’asseoir.

Pendant les deux mois que nous avons passé à la Nouvelle Orléans, Eden subit 40 sessions de HBOT à 1.3 ATA dans un caisson hyperbare.Elle avait une ergothérapie deux fois par semaine. Son tube lui a été enlevé car elle n’en avait plus besoin. Je lui ai enlevé tous les médicaments faisant l’objet d’une ordonnance car elle n’en montrait plus le besoin. Presque tout le « tone » avait quitté son corps. Elle pouvait se mouvoir intentionnellement. Elle pouvait s’asseoir indépendamment, se mouvoir, se dresser, et commençait à entreprendre des pas incertains à la fin de son traitement. Elle a retrouvé tout son vocabulaire et pouvait parler encore mieux qu’avant son accident. Elle a récupéré par miracle.

Son IRM, après 40 sessions de 40 HBOT était normal.

Jusqu’à aujourd’hui, elle a eu plus de 100 sessions de HBOT. Elle a maintenant son propre caisson d’appoint à la maison et nous continuons le traitement sous la supervision du Dr. Harch. Elle marche bien en étant assistée et, pour le reste, elle se comporte comme une enfant de 4 ans. Ses capacités cognitives et son langage sont normaux. Elle continue à progresser. Outre le HBOT, elle est allée au Centre de Plasticité d’Orlando pendant une semaine. Elle continue de l’ergothérapie 3 fois par semaine. de la physiothérapie 3 fois par semaine, une fois en clinique, une fois en piscine et une fois à cheval.

Elle apprend à nager.

Cas d’étude:

Blessure anorexique (presque noyade) histoire de l’enfant de 2 ans, Eden Carlson, qui a défié tous les pronostics et est probablement le premier cas médical de ce type dont le cas d’étude a été publié:

http://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=144;epage=149;aulast=Harch

Article:

https://usat.ly/2gPEPT8

HBOT Locations

As I mentioned before more than 2 years ago my friend from USA started an online closed support group on Facebook for HBOT called “HBOT for Pediatric Neurological Conditions”.  She asked me to be  the admin of  the group and it so happened that she afterwards « gave » me the administration of this group. Now the group  has become big ( more than 1800 members) of parents and professionals from  the hbot feld.

And in fact this is our Hbot locations ( created in collaboration with parents and professionals present on Facebook page) if you want to contact directly referral parent of location or professional I invite you to become member of Facebook group and ask them questions directly.

https://m.facebook.com/groups/1834837990132052

HBOT (Hyperbaric Oxygen Therapy) is a medical treatment which is also used in autism/Cp /anoxic injury etc….

The safety of hyperbaric oxygen treatment – retrospective analysis in 2,334 patients:

https://www.researchgate.net/profile/Shai_Efrati2/publication/303569636_The_safety_of_hyperbaric_oxygen_treatment_-_retrospective_analysis_in_2334_patients/links/5760cfdf08ae244d0370d4da/The-safety-of-hyperbaric-oxygen-treatment-retrospective-analysis-in-2-334-patients.pdf?origin=publication_detail

Oxygen could be toxic if not administered properly, so that’s why I want tell parents about this fact and I advice to take consultation with specialist ( of your choice) before any HBOT treatment ( whichever type of pressure or type of chambers you choose to use it’s safer if treatment monitored by HBOT doctor especially if supplemental oxygen is added)

Part I

Oxygen toxicity:

Protocols for the avoidance of hyperoxia exist in fields where oxygen is breathed at higher-than-normal partial pressures but protocol must be monitored.

But not much centers are doing complete check up ( as i am doing for Marc before/after HBOT)

EKG

Blood tests

Medical tests and checking his tubes and ears

Vision tests

His heart beats / pulse rate and pressure and oxymeter are measured, every day before/and after HBOT

So I know that he doesn’t get oxygen toxicity from his HBOT treatment.

Patients at risk for pulmonary oxygen toxicity should be monitored for oxygen saturation and increased work of breathing. They can be evaluated by pulmonary function testing and chest x-rays which can show signs of ARDS.

(In Israel we did X-Rays for marc and me(as we are going with him inside the chamber)

Similarly, eye exams assessing acuity and looking for lens opacification can be done to detect early ocular oxygen toxicity. (Also did all ayes tests before starting HBOT)

CNS toxicity manifests as described and will often have tachycardia and diaphoresis as well. (as well because my son condition is WPW = tachycardia possible in his case so this point and blood pressure is monitored every day)

Aborting a hyperbaric exposure when these signs are present can prevent seizure occurrence!!

So here or file with docs to read:

Oxygen Toxicity :

The effects of oxygen toxicity may be classified by the organs affected, producing three principal forms:

• Central nervous system, characterised by convulsions followed by unconsciousness, occurring under hyperbaric conditions;

• Pulmonary (lungs), characterised by difficulty in breathing and pain within the chest, occurring when breathing increased pressures of oxygen for extended periods;

• Ocular (retinopathic conditions), characterised by alterations to the eyes, occurring when breathing increased pressures of oxygen for extended periods.

Central nervous system oxygen toxicity can cause seizures, brief periods of rigidity followed by convulsions and unconsciousness, and is of concern to divers who encounter greater than atmospheric pressures. Pulmonary oxygen toxicity results in damage to the lungs, causing pain and difficulty in breathing. Oxidative damage to the eye may lead to myopia or partial detachment of the retina. Pulmonary and ocular damage are most likely to occur when supplemental oxygen is administered as part of a treatment, particularly to newborn infants, but are also a concern during hyperbaric oxygen therapy.

Oxygen toxicity seizures (Bert effect) can occur with hyperbaric oxygen therapy in a dose-dependent relationship. The overall risk may be as frequent as 1 in 2000 to 3000 treatments. However, this risk may be as high as 1 in 200 at higher pressures (2.8 to 3.0 times normal atmospheric pressure or one atmosphere absolute (ATA)) and as low as 1 in 10,000 for treatment at 2 ATA or less. One study looking at the hyperbaric treatment of decompression illnesses noted an overall incidence of oxygen toxicity events of 7%. The incidence of pulmonary toxicity (Smith effect) was 5%, while 2% for central nervous system symptoms, and a seizure rate of 0.6%.

Central nervous system signs and symptoms:

• Headache

• Irritability and anxiety

• Dizziness

• Disorientation

• Hyperventilation

• Hiccups

• Cold shivering

• Fatigue and restless ( difficulty to sleep)

• Tingling in the limbs

• Visual changes such as blurring and tunnel vision

• Tinnitus and Hearing disturbances

• Nausea

• Twitching

• Tonic–clonic seizure

Pulmonary toxicity signs and symptoms:

• Mild tickle sensation on inhalation

• Mild burning on inhalation

• Uncontrollable coughing

• Hemoptysis

• Dyspnea

• Rales

• Fever

• Hyperemia of the nasal mucosa

• CXR shows inflammation and pulmonary edema

Eyes:

• In premature babies, retinopathy of prematurity and retrolental fibroplasia

• Cataract formation (long-term exposure)

And now some studies about and links:

1) Several side effects and complications from hyperbaric oxygen (HBO2) therapy have been described, with varying degrees of seriousness. By far, the two most frequent and benign side effects comprise middle ear barotrauma, which has been noted in up to 2% of treated patients, and can be prevented or minimized by teaching autoinflation techniques, or by inserting tympanostomy tubes. Another frequent complaint is claustrophobia, both during multiplace and monoplace chamber compression, requiring reassurance, coaching and, at times, sedation. Other more rare, but more severe side effects derive from oxygen (O2) toxicity, from the multiple exposures required for chronic treatments, especially progressive myopia, usually transient and reversible after stopping HBO2 sessions, or pulmonary dyspnea, with cough and inspiratory pain. More serious O2-induced seizures happen rarely, at higher O2 pressures, and often during acute treatments in acidotic patients (carbon monoxide poisoning). Source :

https://www.ncbi.nlm.nih.gov/m/pubmed/24984321/

2)Oxygen delivered in supraphysiological amounts is currently under investigation as a therapy for brain injury. Hyperoxia can be delivered to the brain under normobaric as well as hyperbaric conditions. In this study the authors directly compare hyperbaric oxygen (HBO2) and normobaric hyperoxia (NBH) treatment effects.

And here if somebody wants to read comparaison bethween normobaric and hyperbaric oxygen toxicity :

( oh it’s TBI but the same processes we have for all human metabolism for others injuries as well….)

« Hyperbaric O2 has a more robust posttreatment effect than NBH on oxidative cerebral metabolism related to its ability to produce a brain tissue PO2 ≥ 200 mm Hg. However, it appears that O2 treatment for severe TBI is not an all or nothing phenomenon but represents a graduated effect. No signs of pulmonary or cerebral O2 toxicity were present. »

http://thejns.org/doi/abs/10.3171/2009.7.JNS09363

3)clinical trail of dr Harch for oxygen toxicity :

https://clinicaltrials.gov/ct2/show/NCT00592891

4)

And here about oxygen /hemoglobin etc

Under normobaric conditions, the majority of oxygen is transported within the erythrocytes bound to hemoglobin. Breathing of 100% oxygen already results in a 100% saturation of hemoglobin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666443/

5)Dr. J. Lorrain Smith first described the toxic effect of oxygen on the lungs in 1899. He noted that the severity of the effect increased with increasing pO2 and that the effects where largely reversible. As shown in the diagram, the toxic effects of oxygen at partial pressures between 0.45 ATA and 1.6 ATA are primarily on the lungs while the toxic effect at pO2s over 1.6 ATA are primarily on the brain.

The earliest sign of pulmonary (lung) oxygen toxicity is a mild irritation in the trachea (throat) that is made worse with deep inspiration. A mild cough develops next, followed by more severe irritation and cough until inspiration becomes quite painful and the cough becomes uncontrollable. If exposure to oxygen is continued, the person will notice chest tightness, difficulty breathing, shortness of breath, and if exposure is continued long enough, the person will die, from lack of oxygen! The progressive damage to the lungs eventually makes it impossible for the oxygen to get to the blood as it passes through the lungs. The time to onset of symptoms is highly variable but most individuals can tolerate 12-16 hours of oxygen at 1.0 ATA, 8-14 hours at 1.5 ATA, and 3-6 hours at 2.0 ATA before developing mild symptoms. There are several ways to track developing pulmonary oxygen toxicity but the most sensitive and accurate is the development of symptoms. A second technique is to monitor the vital capacity. Vital capacity (the amount of air that can be moved in one large breath) decreases with increasing pulmonary toxicity. A reduction of approximately 2% in vital capacity correlates with mild symptoms while a reduction of 10% correlates symptoms so severe that most individuals will not voluntarily continue breathing oxygen. These mild effects are completely reversible and no permanent lung damage occurs. However, the damage will take 2 to 4 weeks to heal. The pathology of pulmonary oxygen toxicity is understood but beyond the scope of this discussion.

A third way to keep track, in rough terms, of pulmonary oxygen toxicity is to keep track of the oxygen exposure. This technique is called calculating the Unit Pulmonary Toxic Dose (UPTD) and one UPTD is equivalent to breathing 100% oxygen, for one minute, at 1.0 ATA. As a guide, 615 UPTDs in one day will cause a 2% reduction in vital capacity and 1,425 units will cause a 10% decrease. There are several different ways to calculate the UPTD (some try to correct for increasing toxic effects with increasing dose, in addition to the simple pO2) and there is quite wide variation in individual tolerance so that symptoms are still the best guide. The situation where UPTDs are most useful is in planning a large number of dives, in a few days, all involving a large amount of oxygen decompression or CCR diving. Even then, the dive plan may have to be altered if the diver develops symptoms of pulmonary toxicity.

The first and most important method to prevent pulmonary oxygen toxicity is to limit exposure to the lowest possible pO2 for the shortest period of time.

The second method to prevent pulmonary oxygen toxicity is to provide air breaks.

https://www.diverite.com/articles/oxygen-toxicity-signs-and-symptoms/

Part II

HBOT fire security and obligations:

NFPA 99 2015 Chapter 14 Hyperbaric Facility

https://lookaside.fbsbx.com/file/NFPA%2099%202015%20edition%20Chapter%2014%20Hyperbaric%20Facility.pdf?token=AWxiQziqKEpH39UAWk1tXNoZL3pOkrprOEtwFAgnaj74UiEojpeo1L4VwaXwL-0c3fNw5t5oDQwZ2pZfPqe97Gc_tOEnD-akvx_6NDKSHoqJUfnjG0hVFhQ2Ho2bwX_wp1WIy4qM6diphqVLoENpJjaGWu6YmILowONlpfaLud83lrckYW3gf7TrmjlMi-NdVAeaD2dorUbV-CYLlUs6EPE7fUGZqGHPzcghHqfcuN2XrQ

2012 NFPA Ch 14 student handout

https://lookaside.fbsbx.com/file/NFPA%20Chapter%2014%202012.pdf?token=AWwTrHPxLWwpjFFt-Po7POjnMtVWQ6K8-SxjgAvQWv0kz5lZA5K11SYmg8FbrnPsH8e3XQP8vkH1WsLk0BWvC4IXOAZ1a45i69CCGHOa7lL46-YOwjV5ADu6rY2YovbE1rbi98NayH2mxJyEPEBpDc5L_cRnfbUR–fbXsPPVLIdQ8i_sIGgh6gh9rGXke16FPffkZBCG1vmjFp6I3bp_Ayd

Thanks Svetlana

In this article i will tell you about this small girl:

Emelynn. She had near drowning accident at 18-month-old. And she is one of “Hbot miraculous healing “….

http://www.youtube.com/watch?v=NfXB-2F7lUY

I post the exact words of Dorothy Mae Davis mother of Emelynn:

“I’m going to try to keep this as short and to the point as possible. Not that I dont want to talk about it, I just don’t want to overwhelm anyone with a long post so please feel free to ask any questions, anytime. My daughter Emelynn nearly drowned last summer in our pool. It was warm water (June in Arizona). As far as we can tell she was down upwards of 10 minutes. Another 10-15 minutes or so of CPR. Her heart and lungs were strong from the beginning. Her MRI showed « moderate global injury ». She was also blind for about 5 weeks due to CVI. We were in the hospital and inpatient rehab a total of 7 weeks. Started HBOT right after coming home. We have done 40 dives at 1.3 and 20 more at 1.5. After the first 40 dives a new MRI showed « mild intermittent atrophy ». We were told she would « never walk, may learn a few words over her lifetime and probably be able to follow a few simple commands. That she would be wheelchair bound and spend most of her time spaced out and not able to interact with people around her. Her life expectancy was 30 years with excellent care. » She was also on 5 seizure meds. We are a little over 1 year out from her accident and while her speech is still delayed and her coordination is still off, she walks, talks, feeds herself, bathes herself (with instruction) and helps dress herself. We weaned off all meds and onto CBD oil and eventually off of that too. Our nuerologist is an atheist and does not believe in « miracles » but when asked what he thought of her, he said « all I can say is that she is a miracle. ». He does not believe that HBOT or CBD had anything to do with her recovery, that it was her body naturally healing itself. Whatever he chooses to beleive is fine with me, because I know that HBOt saved my baby and God carried us through. This video was taken a couple of weeks before the 1 year anniversary of her drowning on June 10, 2017. In the comments I will link to the news story a local paper did on us if you want to read it. Please feel free to ask any questions. I would not have made it this far without amazing people like Kristal Carlson (Eden’s mother) who answered (and still does) my many questions. I hope my miracle baby inspires you all and that you all have great results if you choose to go with HBOT. 💜💋🇺🇸”

And on link article published about this family:

http://www.phoenixnewtimes.com/news/buckeye-family-heals-together-after-drowning-accident-9969879

Français:

Je veux vous parler histoire de cet fille de usa : Emelynn et hbot. Sa maman Dorothy Mae Davis m’a donné permission de poster son vidéo pour que en france aussi les parents se réveil et se rendre compte que hbot peut rehalment aider ici le cas anoxie cérébrale est est presque noyé à l’âge de 18 mois….

http://www.youtube.com/watch?v=NfXB-2F7lUY

Ici traduction en français : ( directement poste de sa maman sur page de mon fils donc c’est exactement ses paroles pas les miennes) 🙂

« Je vais essayer de garder cela aussi court et précis que possible. Ce n’est pas que je ne veux pas en parler, je ne veux pas submerger quelqu’un avec un long post alors n’hésitez pas à poser des questions, à tout moment. Ma fille Emelynn s’est presque noyée l’été dernier dans notre piscine. C’était de l’eau chaude (juin en Arizona). Pour autant que nous puissions dire qu’elle était dans l’eau 10 minutes. Encore 10-15 minutes de RCR. Son cœur et ses poumons étaient en arêtes dès le début. Son IRM a montré « une lésion globale modérée ». Elle était également aveugle pendant environ 5 semaines en raison de CVI. Nous étions à l’hôpital et en cure médicales pour un total de 7 semaines. Commencé HBOT juste après être rentré à la maison. Nous avons fait 40 plongées à 1,3 ata et 20 de plus à 1,5ata Après les 40 premières plongées, une nouvelle IRM a montré une « légère atrophie intermittente ». On nous a dit a l’hôpital qu’elle «ne marcherait jamais, qu’elle apprendrait peut-être quelques mots au cours de sa vie et qu’elle serait probablement capable de suivre quelques commandes simples qu’elle serait en fauteuil roulant et qu’elle passerait le plus clair de son temps à ne pas pouvoir interagir avec les autres. Son espérance de vie était de 30 ans avec d’excellents soins.  » Elle était également sur 5 médicaments. Nous sommes à un peu plus d’un an de son accident et alors que son discours est toujours retardé et sa coordination est toujours éteinte, elle se promène, parle, se nourrit, se baigne (avec instruction) et aide à s’habiller. Nous nous sommes sevrés tous les médicaments et sur l’huile de CBD et finalement hors de cela aussi. Notre nuerologue est athée et ne croit pas aux « miracles » mais quand on lui demande ce qu’il pense d’elle, il dit « tout ce que je peux dire, c’est qu’elle est un miracle ». Il ne croit pas que l’OHB ou le CBD ait quelque chose à voir avec son rétablissement, que c’est son corps qui se guérit naturellement. Tout ce qu’il choisit de croire est bon pour moi, parce que je sais que HBOt a sauvé mon bébé et que Dieu nous a transportés. Cette vidéo a été prise quelques semaines avant le premier anniversaire de sa noyade le 10 juin 2017. Dans les commentaires, je post un reportage local qu’un journal local a fait sur nous si vous voulez le lire. N’hésitez pas à poser des questions. Je ne l’aurais pas fait jusqu’ici sans des gens extraordinaires comme Kristal Carlson (la mère d’Eden) qui a répondu (et continue de le faire) à mes nombreuses questions. J’espère que mon miracle bébé vous inspire tous et que vous avez tous d’excellents résultats si vous choisissez d’aller avec HBOT. 💜💋🇺🇸 »

Et ici article en anglais pour cet fille:

http://www.phoenixnewtimes.com/news/buckeye-family-heals-together-after-drowning-accident-9969879

Et ici groupe français de mon fils:

https://m.facebook.com/groups/333972306943984

Et group anglophone pour quelqu’un qui intéressée ( on a les professionnels et MD de hbot dans cet groupe donc vous pouvez avoir leur réponses sur vos concrètes cas si vous demandais :

https://m.facebook.com/groups/1834837990132052

Study which makes me decide to go to Israel and do Hyperbare for my son:

First one it was about cardiac arrest survivors:

( my son is one of them so it’s normal I wanted to go to the center Hyperbare where they did scientific study about):

https://www.researchgate.net/profile/Shai_Efrati2/publication/281875707_Hyperbaric_oxygen_can_induce_neuroplasticity_and_improve_cognitive_functions_of_patients_suffering_from_anoxic_brain_damage/links/55ff7fdb08aeba1d9f8407f6/Hyperbaric-oxygen-can-induce-neuroplasticity-and-improve-cognitive-functions-of-patients-suffering-from-anoxic-brain-damage.pdf?origin=publication_detail

“Anoxic Brain Damage (ABD)

Cognitive impairment may occur in 42-50% of cardiac arrest survivors. An additional pilot study conducted at the Sagol Hyperbaric Center at Assaf Harofe Medical Center, where patients were treated with Hyperbaric Oxygen (HBOT) 0.5-7.5 (mean 2.6+_0.6 years)after the cardiac arrest, Even though HBOT was started at the late chronic phase, it induced significant cognitive improvements in all of the patients. The clinical improvements were well documented by neuro-cognitive tests and correlated with improved ability to perform the activities of daily living and quality of life. The most significant measurable improvements were in executive functions, attention and memory. The clinical improvement correlated with metabolic improvement of the injured brain tissue as was well visualized by brain metabolic imaging.”

( read subtitles ) the biggest hbot center in Israel ( and prof dr Efrati)

You have his cv and scientific publications at the end of cv

http://www.assafh.org/Personnel/Documents/Shai%20Efrati%20CV%20and%20publications.pdf

Second study which influenced my decision was about stroke patients ( why stroke? Because even if mechanism of stroke is different from anoxic injury the rehabilitation programs are absolutely the same as for anoxic injured as for stroke injured patients) so this study was one of the best study I read for Hbot with spect scans and comparaisons:

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053716

https://youtu.be/Dh-BIYkgLHQ

Video explanation may be more easy for some of you?

So of cause afterwards I found much more studies to read 😉 and I can shere here part of them:

CP children’s:

Read this very good study (for cp)

http://www.jpands.org/vol12no4/marois.pdf

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

http://www.assafh.org/clinic/Hifrbaric/Documents/Intensive%20rehabilitation%20combined%20with%20HBO2%20therapy%20in%20children%20with%20cerebral%20palsy_A%20controlled%20longitudinal%20study%202014.pdf

http://hyperbaricstudies.com/wp-content/uploads/Hyperbaric-Therapy-Based-Multimode-Therapy-for-children-with-Cerebral-Palsy.pdf

Dr Efrati :

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

http://www.assafh.org/clinic/Hifrbaric/Documents/Intensive%20rehabilitation%20combined%20with%20HBO2%20therapy%20in%20children%20with%20cerebral%20palsy_A%20controlled%20longitudinal%20study%202014.pdf

* Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053716

* Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079995

* Improvement of Memory Impairments in Post stroke Patients by Hyperbaric Oxygen Therapy

http://www.assafh.org/clinic/Hifrbaric/Documents/ASAF836%20EFRATI%208.12.2014.pdf

* Intensive rehabilitation combined with HBO2 therapy in children with cerebral palsy: A controlled longitudinal study

http://www.assafh.org/clinic/Hifrbaric/Documents/Intensive%20rehabilitation%20combined%20with%20HBO2%20therapy%20in%20children%20with%20cerebral%20palsy_A%20controlled%20longitudinal%20study%202014.pdf

* Oxygen – a limiting factor for brain recovery

http://www.assafh.org/sites/en/clinic/Hifrbaric/Documents/Oxygen%20-%20a%20limiting%20factor%20for%20brain%20recovery.pdf

* Reflection on the neurotherapeutic effects of hyperbaric oxygen

http://www.assafh.org/sites/en/clinic/Hifrbaric/Documents/Reflection%20on%20the%20neurotherapeutic%20effects%20of%20hyperbaric%20oxygen.pdf

Dr Harch:

http://www.therapiehyperbare.com/images/hyperbare/2004-06_harch_lphbot_eparent.pdf

(En français) dr Marois :

https://www.chusj.org/fr/Calendrier-salle-presse/nouvelles/actualites/2014/Nouvelle-recherche-sur-l-oxygenotherapie-hyperbare

http://www.fontainesdenergie.com/thb/articles/2013-02-14_introduction_oth_pour_les_parents.html

CP and neurology:

http://www.therapiehyperbare.com/images/hyperbare/2004-06_harch_lphbot_eparent.pdf

Anoxic injury (near drowning)

2-year-old Eden Carlson’s road to recovery has defied the odds and is possibly the first medical case of its kind.

case of study published:

http://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=144;epage=149;aulast=Harch

https://usat.ly/2gPEPT8

Interview with Dr. Kenneth P. Stoller: Hyperbaric oxygen therapy (HBOT), Autism, Aspartame and Mercury

https://www.researchgate.net/profile/Kenneth_Stoller/publication/228362283_Interview_with_Dr_Kenneth_P_Stoller_Hyperbaric_oxygen_therapy_HBOT_Autism_Aspartame_and_Mercury/links/5446af840cf2d62c304f7306/Interview-with-Dr-Kenneth-P-Stoller-Hyperbaric-oxygen-therapy-HBOT-Autism-Aspartame-and-Mercury.pdf?origin=publication_detail

Rossignol autisme:

https://lookaside.fbsbx.com/file/07_RossignolHBOT%20pathophysiologyautism2006.pdf?token=AWzMJG-McmMfxnai8pOn67Jtjbl_pSI_RiPFkcpvxeTNWI2QXDKsPNU6yz0C7OI6I5plkUgRXEARdiQRIA3Vy2BJrHYfvGb_EFpcLw6SjY8Jz0bzICYXRdepEHtqOChCLNI1Ts0jLHLtwW7tMi04xkLA5m7nHZ89xLjubPQEzRZYppkvAF__RtU07Qbys_9dhzi2yaus2eLfOK7THHI6do8u

Stem cell mobilization by hyperbaric oxygen:

https://www.ncbi.nlm.nih.gov/m/pubmed/16299259/

(En français) dr Marois :

https://www.chusj.org/fr/Calendrier-salle-presse/nouvelles/actualites/2014/Nouvelle-recherche-sur-l-oxygenotherapie-hyperbare

http://www.fontainesdenergie.com/thb/articles/2013-02-14_introduction_oth_pour_les_parents.html

In Russia we use Hbot for pregnant women ( exectly when we suspect luck of oxygen for baby)… very smal pressure an only 34% oxygen…

I have study published ( in Russian)

For the first time, a device was developed (patent for utility model No. 56117 of April 17, 2006) and a modified procedure (rationalization proposal No. 503 of 21.03.2006) for hyperbaric oxygenation in pregnant women with chronic placental insufficiency.

In this study you have comparison in table for women’s with Hbot treatments during pregnancy (best APGAR score for just born children’s)

Medical Theses

http://medical-diss.com/medicina/optimizatsiya-terapii-hronicheskoy-platsentarnoy-nedostatochnosti-s-ispolzovaniem-giperbaricheskoy-oksigenatsii#ixzz4uY7W4s5z

For pregnant women’s with anemia:

https://www.fundamental-research.ru/ru/article/view?id=33839

Women’s with epilepsy was excluded from trail

So it was 1,3 -1,5 ata hard hbot

At 6-8 weeks of pregnancy first session 5-7 days of hbot 40 min ( only 5-7 days consecutive)

Than at 16-18 weeks of pregnancy ( also hbot only for 5-7 days)

And than at 22-24 weeks of pregnancy ( only for 5-7 days)….

Conducting HBO positively influenced the clinical course of pregnancy. This is evidenced by the rapid normalization of the general condition, the disappearance of myometrium hypertension in pregnant women with the threat of termination of pregnancy. Against the background of treatment, the hemoglobin level increased in the studied patients of both groups. In this case, in cases of HBO, this increase was more pronounced. If the level of hemoglobin in the main group was 86.5 ± 1.5 g / l before the course of HBO, then after receiving the full course of HBO, 110.5 ± 1.5 g / l. In patients who received therapy without HBO, the hemoglobin indices during the whole pregnancy did not differ significantly and on average averaged 9.0 ± 1.3 mmol / l. Against the background of treatment with HBO, there was a significant increase in the number of red blood cells – by 0.12 ∙ 1012 / l (p <0.05), platelets – by 9.5 ∙ 10 9 l (p <0.05), protein level – 3.09 g / l (p <0.01) in the blood in relation to the indicators in the group with standard treatment.